Biochemical features of glycolysis in cancer cells with different metastatic potential

IF 0.6 4区物理与天体物理 Q4 PHYSICS, APPLIED

Low Temperature Physics Pub Date : 2024-03-26 DOI:10.1063/10.0024974

Solomia Hnatiuk, Denys Kolesnyk, Galina Solyanik

引用次数: 0

Abstract

It is known that, compared with normal cells, cancer cells are characterized by an intensification of glycolysis and an increase in glucose uptake to ensure high proliferative activity. Meanwhile, the question of the relationship between the intensity of glycolysis and the metastatic potential of tumor cells remains open. The aim of the study was to determine the rate of glucose uptake (GCR) and lactate production (LPR) by Lewis lung carcinoma cells with high (LLC) and low metastatic potential (LLC/R9) during 1-day growth in vitro under standard incubation conditions. The results showed that glycolysis intensity was significantly higher in low-metastatic Lewis lung carcinoma cells compared to the high-metastatic cells.

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具有不同转移潜能的癌细胞中糖酵解的生化特征

众所周知，与正常细胞相比，癌细胞的特点是加强糖酵解和增加葡萄糖摄取，以确保高增殖活性。与此同时，糖酵解强度与肿瘤细胞转移潜力之间的关系问题仍未解决。本研究旨在测定高转移潜能（LLC）和低转移潜能（LLC/R9）的刘易斯肺癌细胞在标准培养条件下体外生长1天期间的葡萄糖摄取率（GCR）和乳酸生成率（LPR）。结果表明，低转移性刘易斯肺癌细胞的糖酵解强度明显高于高转移性细胞。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Low Temperature Physics 物理-物理：应用

CiteScore

1.20

自引率

25.00%

发文量

138

审稿时长

3 months

期刊介绍： Guided by an international editorial board, Low Temperature Physics (LTP) communicates the results of important experimental and theoretical studies conducted at low temperatures. LTP offers key work in such areas as superconductivity, magnetism, lattice dynamics, quantum liquids and crystals, cryocrystals, low-dimensional and disordered systems, electronic properties of normal metals and alloys, and critical phenomena. The journal publishes original articles on new experimental and theoretical results as well as review articles, brief communications, memoirs, and biographies. Low Temperature Physics, a translation of the copyrighted Journal FIZIKA NIZKIKH TEMPERATUR, is a monthly journal containing English reports of current research in the field of the low temperature physics. The translation began with the 1975 issues. One volume is published annually beginning with the January issues.