Drugs with Senolytic Activity: Prospects and Possible Limitations

Q3 Agricultural and Biological Sciences
G. V. Morgunova, A. N. Khokhlov
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引用次数: 0

Abstract

The search for and testing of drugs with senolytic activity is a new direction in gerontology. The increasing number of “senescent” cells with age contributes to the development of age-related diseases and chronic non-infectious inflammation. Removing “senescent” cells or suppressing their influence on surrounding tissues seems like a logical step to improve quality of life and possibly prolong it. However, drugs with senolytic and senomorphic activity in model systems induce the development of a number of side effects in clinical trials. In this review, we discuss the main advances in senotherapy, the prospects for the use of senotherapeutics, and the limitations that researchers and clinicians may encounter.

具有衰老活性的药物:前景与可能的局限性
摘要寻找和测试具有衰老活性的药物是老年学的一个新方向。随着年龄的增长,"衰老 "细胞的数量也在增加,这导致了老年相关疾病和慢性非感染性炎症的发生。清除 "衰老 "细胞或抑制其对周围组织的影响似乎是提高生活质量并可能延长寿命的合理步骤。然而,在模型系统中具有衰老分解和衰老形态活性的药物在临床试验中会诱发一系列副作用。在这篇综述中,我们将讨论衰老疗法的主要进展、使用衰老治疗药物的前景以及研究人员和临床医生可能遇到的限制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Moscow University Biological Sciences Bulletin
Moscow University Biological Sciences Bulletin Agricultural and Biological Sciences-Agricultural and Biological Sciences (all)
CiteScore
1.00
自引率
0.00%
发文量
18
期刊介绍: Moscow University Biological Sciences Bulletin  is forum for research in all important areas of modern biology. It publishes original work on qualitative, analytical and experimental aspects of research. The scope of articles to be considered includes plant biology, zoology, ecology, evolutionary biology, biophysics, genetics, genomics, proteomics, molecular biology, cell biology, biochemistry, endocrinology, immunology, physiology, pharmacology, neuroscience, gerontology, developmental biology, bioinformatics, bioengineering, virology, and microbiology.
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