{"title":"Arylation of quinoxalinones at room temperature under metal and base free-conditions","authors":"","doi":"10.1007/s00706-024-03188-2","DOIUrl":null,"url":null,"abstract":"<h3>Abstract</h3> <p>A mild and efficient method for the arylation of quinoxalinones are described using aryldiazonium tetrafluoroborates as aryl source. Reactions proceeds at room temperature in a short reaction time of 1 h without metal catalysts and bases. Broad functional group tolerance was observed with good yields of products even at gram scale reaction. Control experiments suggest that the reactions proceed through a radical pathway. Furthermore, the present protocol applied for the successive synthesis of three biologically active molecules. Overall, the method offers a convenient and versatile approach for the synthesis of arylated quinoxalinones.</p> <span> <h3>Graphical abstract</h3> <p> <span> <span> <img alt=\"\" src=\"https://static-content.springer.com/image/MediaObjects/706_2024_3188_Figa_HTML.png\"/> </span> </span></p> </span>","PeriodicalId":19011,"journal":{"name":"Monatshefte für Chemie / Chemical Monthly","volume":"66 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Monatshefte für Chemie / Chemical Monthly","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s00706-024-03188-2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
A mild and efficient method for the arylation of quinoxalinones are described using aryldiazonium tetrafluoroborates as aryl source. Reactions proceeds at room temperature in a short reaction time of 1 h without metal catalysts and bases. Broad functional group tolerance was observed with good yields of products even at gram scale reaction. Control experiments suggest that the reactions proceed through a radical pathway. Furthermore, the present protocol applied for the successive synthesis of three biologically active molecules. Overall, the method offers a convenient and versatile approach for the synthesis of arylated quinoxalinones.
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