Antiarrhythmic drugs

IF 0.2 Q4 ANESTHESIOLOGY

Anaesthesia and Intensive Care Medicine Pub Date : 2024-03-06 DOI:10.1016/j.mpaic.2024.02.001

Georgina Sutcliffe, Benjamin Jones, Cally Burnard

引用次数: 0

Abstract

Around 3.7 million people worldwide die each year from cardiac arrhythmias. Despite advances in catheter ablation therapies and implantable devices, there have been few advances in pharmacological therapy. Advances in the understanding of channel subtypes has led to the proposed modification of the Vaughan Williams classification system. However, each drug has a unique pharmacokinetic profile meaning that often the class of a drug bears little clinical relevance. Many drugs also have sites of action outside of their class which may account for the generation of proarrhythmias. The advances in understanding of specific ion channel subtypes may provide the opportunity for target-specific drugs with improved safety profiles.

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抗心律失常药物

全世界每年约有 370 万人死于心律失常。尽管导管消融疗法和植入式设备取得了进步，但药物疗法却鲜有进展。随着对通道亚型认识的不断深入，人们提出了修改沃恩-威廉姆斯分类系统的建议。然而，每种药物都有其独特的药代动力学特征，这意味着药物的类别往往与临床关系不大。许多药物也有其类别之外的作用部位，这可能是导致前心律失常的原因。随着对特定离子通道亚型认识的不断深入，可能会有机会开发出安全性更好的靶向药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anaesthesia and Intensive Care Medicine ANESTHESIOLOGY-

CiteScore

0.50

自引率

0.00%

发文量

152

期刊介绍： Anaesthesia and Intensive Care Medicine, an invaluable source of up-to-date information, with the curriculum of both the Primary and Final FRCA examinations covered over a three-year cycle. Published monthly this ever-updating text book will be an invaluable source for both trainee and experienced anaesthetists. The enthusiastic editorial board, under the guidance of two eminent and experienced series editors, ensures Anaesthesia and Intensive Care Medicine covers all the key topics in a comprehensive and authoritative manner. Articles now include learning objectives and eash issue features MCQs, facilitating self-directed learning and enabling readers at all levels to test their knowledge. Each issue is divided between basic scientific and clinical sections. The basic science articles include anatomy, physiology, pharmacology, physics and clinical measurement, while the clinical sections cover anaesthetic agents and techniques, assessment and perioperative management. Further sections cover audit, trials, statistics, ethical and legal medicine, and the management of acute and chronic pain.