Synthetic marvels in tuberculosis research: An in-depth review of 1,3,4-oxadiazole derivatives as antitubercular agents

Abstract

Given the growth in drug-resistant and inactive cases of tuberculosis, it is imperative to develop novel, potent chemicals to treat this deadly illness. Compounds containing oxadiazole are one such class of chemicals that could be taken into consideration to meet this requirement. The biological action of compounds with a 1,3,4-oxadiazole ring in their structure is diverse. The numerous functions of a five-member heterocyclic ring have sparked interest of medicinal and synthetic organic chemists involved in the design of novel molecules. The development of the small and straightforward 1,3,4-oxadiazole nucleus, which is found in a variety of compounds with significant pharmacological capabilities like antitubercular and is intended to assess novel goods, has a lot of potential. This review article highlights the various approaches used to generate the 1,3,4-oxadiazole nucleus, the targeted activity of 1,3,4-oxadiazole derivatives and their structure activity relationship to produce potential antitubercular drugs.