Congenital cardiac anomalies in non-syndromic cleft lip and cleft palate patients: A systematic review and meta-analysis

IF 1.3 4区 医学 Q3 PEDIATRICS
Bindey Kumar, Priyankar Singh, Alok Ranjan, Tulika Singh, Nimmi Singh,  Kriti, Swati Singh, Siddharth Singh, Navin Mishra, Arbind Kumar Sharma
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Abstract

The aim was to establish a specific and definite connection between non-syndromic orofacial cleft patients and associated congenital heart disease (CHD). Following PRISMA guidelines, selective databases were searched for data collection. Studies showing a definite association of CHD with orofacial cleft were included, and studies non-specific of the association of orofacial cleft with CHD were excluded. Data extraction criteria were study design, frequency of CHD in overall non-syndromic orofacial cleft and in specific cleft type, and most prevalent congenital cardiac anomaly. DerSimonian Laird random effects model was used to estimate the pooled proportion of CHD, along with corresponding 95% confidence intervals (CIs) for each measure. Publication bias was assessed using Fail-Safe N analysis and the Rosenthel approach. Of a total of 182 articles searched, only 30 studies were assessed. The overall pooled estimate of the proportion of CHD in total cleft lips/palates was 16% (95% CI: 13–19). The odds of developing CHD in cleft palates was 4.08 times more as compared to cleft lips with 95% CIs of 3.86–4.33, and 1.65 more as compared to cleft lips and palates both with 95% CI of 1.52–1.68. We affirm the upsurging prevalence of CHD in non-syndromic cleft children and vehemently propose that it is of utmost importance to inculcate it in practice and policy-making to screen all non-syndromic orofacial cleft children for congenital cardiac anomaly. This study was registered on PROSPERO (ID no. CRD42023391597) on February 24, 2023.

非综合征唇裂和腭裂患者的先天性心脏畸形:系统回顾和荟萃分析。
目的是确定非综合征口面裂患者与相关先天性心脏病(CHD)之间的具体明确联系。根据 PRISMA 指南,我们选择性地搜索了数据库以收集数据。其中包括显示先天性心脏病与口唇裂有明确关联的研究,而不包括口唇裂与先天性心脏病关联的非特异性研究。数据提取标准为研究设计、非综合征性口面裂隙和特定裂隙类型中出现先天性心脏病的频率,以及最常见的先天性心脏异常。采用DerSimonian Laird随机效应模型估算CHD的汇总比例,以及每项指标相应的95%置信区间(CIs)。采用Fail-Safe N分析和Rosenthel方法评估发表偏倚。在总共搜索到的 182 篇文章中,仅对 30 项研究进行了评估。唇裂/腭裂患者罹患先天性心脏病比例的总体汇总估计值为 16% (95% CI: 13-19)。腭裂患先天性心脏病的几率是唇裂的 4.08 倍(95% CI 为 3.86-4.33),是唇腭裂的 1.65 倍(95% CI 为 1.52-1.68)。我们肯定了非综合征口裂儿童中先天性心脏病发病率的急剧上升,并强烈建议在实践中和政策制定中灌输对所有非综合征口裂儿童进行先天性心脏异常筛查的重要性。本研究已于 2023 年 2 月 24 日在 PROSPERO 上注册(ID 号:CRD42023391597)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Congenital Anomalies
Congenital Anomalies PEDIATRICS-
自引率
0.00%
发文量
49
审稿时长
>12 weeks
期刊介绍: Congenital Anomalies is the official English language journal of the Japanese Teratology Society, and publishes original articles in laboratory as well as clinical research in all areas of abnormal development and related fields, from all over the world. Although contributions by members of the teratology societies affiliated with The International Federation of Teratology Societies are given priority, contributions from non-members are welcomed.
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