MMP1, MMP9, MMP11 and MMP13 in melanoma and its metastasis - key points in understanding the mechanisms and celerity of tumor dissemination.

IF 1.2 4区 医学 Q4 DEVELOPMENTAL BIOLOGY
Bogdan Stelian Mastalier Manolescu, Angela Mădălina Lazar, George Sorin Ţiplica, Sabina Andrada Zurac, Adrian Reboşapcă, Bogdan Andreescu, Cristiana Gabriela Popp
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引用次数: 0

Abstract

Background: Matrix metalloproteinase (MMP)1, MMP9, MMP11, and MMP13 are overexpressed in malignant melanoma (MM), being associated with tumor invasive phase, metastases, and more aggressive neoplastic phenotypes.

Aim: The main objective of the current study was to correlate the expression of the MMPs with the evolution of MM toward distant metastasis.

Patients, materials and methods: We designed a retrospective cohort study, including 13 patients with metastatic MM. Data concerning age, sex, localization of the primary lesion and metastasis, and histological and immunohistochemical features (intensity of expression and percent of positive cells for MMPs) were statistically processed.

Results: The time between the diagnosis of primitive melanoma and the diagnosis of metastasis ranged between 0 and 73 months, with a mean value of 18.3 months. The metastases rich in MMP1- and MMP9-positive cells occurred earlier than the metastases with low levels of positive cells. The mean period until metastasis was shorter for the MMP1-expressing tumors than the ones without MMP1 expression. MMP13 expression in the tumor and its metastasis was significantly linked with the time until the metastasis occurrence.

Conclusions: This study emphasizes the roles of MMP1, MMP9, and MMP13 in the process of metastasis in melanoma and the opportunity to use them as therapeutic targets and surveillance molecules.

黑色素瘤及其转移中的 MMP1、MMP9、MMP11 和 MMP13--了解肿瘤扩散机制和速度的关键点。
背景:基质金属蛋白酶(MMP)1、MMP9、MMP11和MMP13在恶性黑色素瘤(MM)中过度表达,与肿瘤浸润期、转移和更具侵袭性的肿瘤表型相关:我们设计了一项回顾性队列研究,包括13名转移性MM患者。我们对患者的年龄、性别、原发病灶和转移灶的位置、组织学和免疫组化特征(MMPs的表达强度和阳性细胞百分比)等数据进行了统计处理:原始黑色素瘤确诊与转移瘤确诊之间的时间为 0 至 73 个月,平均值为 18.3 个月。MMP1和MMP9阳性细胞较多的转移瘤比阳性细胞较少的转移瘤发生得早。与无MMP1表达的肿瘤相比,MMP1表达的肿瘤发生转移的平均时间更短。肿瘤及其转移灶中MMP13的表达与转移发生的时间有显著关系:本研究强调了MMP1、MMP9和MMP13在黑色素瘤转移过程中的作用,以及将它们作为治疗靶点和监测分子的机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.70
自引率
20.00%
发文量
221
审稿时长
3-8 weeks
期刊介绍: Romanian Journal of Morphology and Embryology (Rom J Morphol Embryol) publishes studies on all aspects of normal morphology and human comparative and experimental pathology. The Journal accepts only researches that utilize modern investigation methods (studies of anatomy, pathology, cytopathology, immunohistochemistry, histochemistry, immunology, morphometry, molecular and cellular biology, electronic microscopy, etc.).
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