Magnetic resonance imaging combined with histological evaluation of repair process using the microfracture technique in an association of osteocartilaginous and meniscal surgically induced lesions of the knee. In vivo experiment on a rabbit model.

IF 1.2 4区 医学 Q4 DEVELOPMENTAL BIOLOGY
Jenel Marian Pătraşcu, Sorin Florescu, Silviu Brad, Bogdan Corneliu Andor, Iosif Ilia, Ştefan Iulian Stănciugelu, Romeo Teodor Cristina
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Abstract

The present research study aimed to assess magnetic resonance imaging (MRI) changes and histological findings in the therapeutic effects of microfractures in the treatment of complex animal knee lesions resulting from osteochondral and meniscal defects resulting from non-total meniscectomies. The anterior cruciate ligament lesions are also proven to facilitate the development of osteoarthritis in the knee and worsen the prognosis. Surgery was performed on the right knee joint of 22 male rabbits in order to partially remove the anterior horn of the internal meniscus and to induce an osteochondral defect at the level of the internal femoral condyle. The induced lesion complex was aimed to simulate a clinical situation that occurs frequently in orthopedic practice when young adults undergo partial meniscectomy and at the time of surgery, an osteochondral defect is diagnosed. Rabbits were separated into two study groups: the control (C1) group and the microfractures (MF2) group. After the induced cartilage defect and partial meniscectomy, both groups were followed-up for six months using detailed MRI. Also, anatomical specimens were histologically analyzed to show modifications and signs of healing process, along with complications, in the study group. The results showed that the microfracture group had better results concerning articular surface defect healing in comparison to the control group. Our results suggest that microfractures do improve results concerning surface contact healing and serial MRI studies can be useful in observing the remodeling process in dynamics.

利用微骨折技术对膝关节骨软骨和半月板手术引起的损伤的修复过程进行磁共振成像和组织学评估。兔子模型的活体实验。
本研究旨在评估磁共振成像(MRI)变化和组织学发现对微骨折治疗非全半月板切除术造成的骨软骨和半月板缺损导致的复杂动物膝关节病变的疗效。事实证明,前交叉韧带损伤也会促进膝关节骨性关节炎的发展,并使预后恶化。我们对 22 只雄性兔子的右膝关节进行了手术,部分切除了内半月板的前角,并在股骨内髁水平诱发了骨软骨缺损。诱导病变复合体的目的是模拟骨科临床中经常出现的情况,即青壮年接受部分半月板切除术,并在手术时诊断出骨软骨缺损。兔子被分为两个研究组:对照组(C1)和微骨折组(MF2)。在诱导软骨缺损和半月板部分切除术后,两组兔子都接受了为期六个月的详细核磁共振成像随访。此外,还对解剖标本进行了组织学分析,以显示研究组中愈合过程的变化和迹象,以及并发症。结果显示,与对照组相比,微骨折组的关节面缺损愈合效果更好。我们的研究结果表明,微骨折确实能改善表面接触愈合的效果,连续的磁共振成像研究有助于动态观察重塑过程。
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来源期刊
CiteScore
1.70
自引率
20.00%
发文量
221
审稿时长
3-8 weeks
期刊介绍: Romanian Journal of Morphology and Embryology (Rom J Morphol Embryol) publishes studies on all aspects of normal morphology and human comparative and experimental pathology. The Journal accepts only researches that utilize modern investigation methods (studies of anatomy, pathology, cytopathology, immunohistochemistry, histochemistry, immunology, morphometry, molecular and cellular biology, electronic microscopy, etc.).
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