Incidence, Prevalence, and Mortality of Eosinophilic Granulomatosis With Polyangiitis in Korea: A Nationwide Population-Based Study.

IF 4.1 2区医学 Q2 ALLERGY

Allergy, Asthma & Immunology Research Pub Date : 2024-03-01 DOI:10.4168/aair.2024.16.2.168

Ji-Ho Lee, Se Hwa Hong, Iseul Yu, Min-Seok Chang, Sunmin Park, Seok Jeong Lee, Sang-Ha Kim

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引用次数: 0

Abstract

Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare form of vasculitis with multiorgan involvement. The incidence and prevalence of EGPA vary geographically and ethnically. This study investigated the incidence, prevalence, and mortality of EGPA in a nationwide population-based cohort in Korea.

Methods: This retrospective cohort study used data from the National Health Insurance database that covers almost all Korean residents. EGPA was identified using relevant diagnostic codes from 2007 to 2018. Newly diagnosed EGPA cases since 2007 and patients who visited outpatient clinics for EGPA at least three times were included. Age- and sex-adjusted standardized incidence and prevalence rates were analyzed.

Results: A total of 843 patients with EGPA were identified. The mean annual standardized incidence between 2007 and 2018 was 1.2 (per 1,000,000 individuals). The incidence of EGPA has increased from 1.1 (per 1,000,000 individuals) in 2007 to 1.6 (per 1,000,000 individuals) in 2017. The standardized prevalence of EGPA has increased from 1.1(per 1,000,000 individuals) in 2007 to 11.2 (per 1,000,000 individuals) in 2018. The incidence and prevalence of EGPA were higher in women than in men. The standardized mortality rate was 1.61 (95% confidence interval [CI], 1.34-1.93) in total population, 1.59 (95% CI, 1.23-2.02) in males, and 1.63 (95% CI, 1.22-2.13) in females.

Conclusions: The incidence of EGPA has increased over the past decade. Incidence and prevalence rates were higher in females than in males. The overall mortality rate associated with EGPA was higher than that in the general population.

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韩国嗜酸性粒细胞增多性多血管炎的发病率、流行率和死亡率：一项基于全国人口的研究。

目的：嗜酸性粒细胞肉芽肿伴多血管炎（EGPA）是一种罕见的多器官受累的血管炎。EGPA 的发病率和流行率因地域和种族而异。本研究调查了韩国全国人群队列中 EGPA 的发病率、流行率和死亡率：这项回顾性队列研究使用的数据来自国民健康保险数据库，该数据库几乎涵盖了所有韩国居民。从 2007 年到 2018 年，通过相关诊断代码对 EGPA 进行了鉴定。研究纳入了自2007年以来新确诊的EGPA病例，以及至少因EGPA就诊三次的门诊患者。对年龄和性别调整后的标准化发病率和患病率进行了分析：结果：共发现 843 名 EGPA 患者。2007 年至 2018 年间的年平均标准化发病率为 1.2（每 100 万人）。EGPA的发病率从2007年的1.1（每100万人）上升到2017年的1.6（每100万人）。EGPA 的标准化患病率从 2007 年的 1.1（每 100 万人）增加到 2018 年的 11.2（每 100 万人）。女性的 EGPA 发病率和流行率均高于男性。总人口的标准化死亡率为1.61（95%置信区间[CI]，1.34-1.93），男性为1.59（95%置信区间，1.23-2.02），女性为1.63（95%置信区间，1.22-2.13）：在过去十年中，EGPA的发病率有所上升。女性的发病率和流行率均高于男性。与 EGPA 相关的总死亡率高于普通人群。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Allergy, Asthma & Immunology Research ALLERGY-IMMUNOLOGY

CiteScore

6.10

自引率

6.80%

发文量

审稿时长

>12 weeks

期刊介绍： The journal features cutting-edge original research, brief communications, and state-of-the-art reviews in the specialties of allergy, asthma, and immunology, including clinical and experimental studies and instructive case reports. Contemporary reviews summarize information on topics for researchers and physicians in the fields of allergy and immunology. As of January 2017, AAIR do not accept case reports. However, if it is a clinically important case, authors can submit it in the form of letter to the Editor. Editorials and letters to the Editor explore controversial issues and encourage further discussion among physicians dealing with allergy, immunology, pediatric respirology, and related medical fields. AAIR also features topics in practice and management and recent advances in equipment and techniques for clinicians concerned with clinical manifestations of allergies and pediatric respiratory diseases.