Precision allergy molecular diagnosis applications in food allergy.

IF 3 4区医学 Q2 ALLERGY

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-06-01 Epub Date: 2024-03-26 DOI:10.1097/ACI.0000000000000977

Sakura Sato, Motohiro Ebisawa

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引用次数: 0

Abstract

Purpose of review: Precision medicine has become important in the diagnosis and management of food allergies. This review summarizes the latest information regarding molecular allergology, an essential component of food allergy managements.

Recent findings: Component-resolved diagnostics (CRD) can be used to investigate sensitization to allergens based on symptoms and to reveal co-sensitization and/or cross-sensitization in patients with allergies. The following allergen components are known to be associated with symptoms: ovomucoid from eggs, omega-5 gliadin from wheat, and many storage proteins (Gly m 8 from soy, Ara h 2 from peanut, Cor a 14 from hazelnut, Ana o 3 from cashew nut, Jug r 1 from walnut, and Ses i 1 from sesame). Recent studies on allergens of macadamia nuts (Mac i 1 and Mac i 2), almonds (Pru du 6), fish (parvalbumin and collagen), and shrimp (Pem m 1 and Pem m 14) have provided additional information regarding CRD. In addition, Pru p 7 is a risk factor for systemic reactions to peaches and has recently been found to cross-react with cypress and Japanese cedar pollen.

Summary: CRD provides information of individualized sensitization profiles related to symptoms and severity of allergies in patients. Clinical practice based on CRD offers many benefits, such as higher diagnostic accuracy and improved management of individual patients.

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精准过敏分子诊断在食物过敏中的应用。

综述的目的：精准医学在食物过敏的诊断和管理中已变得非常重要。本综述总结了有关分子过敏学的最新信息，分子过敏学是食物过敏管理的重要组成部分：成分解析诊断法（CRD）可用于根据症状调查过敏原的致敏性，并揭示过敏症患者的共敏性和/或交叉致敏性。已知以下过敏原成分与症状有关：鸡蛋中的卵磷脂、小麦中的Ω-5 胶质蛋白和许多贮存蛋白（大豆中的 Gly m 8、花生中的 Ara h 2、榛子中的 Cor a 14、腰果中的 Ana o 3、核桃中的 Jug r 1 和芝麻中的 Ses i 1）。最近对澳洲坚果（Mac i 1 和 Mac i 2）、杏仁（Pru du 6）、鱼（副卵磷脂和胶原蛋白）和虾（Pem m 1 和 Pem m 14）过敏原的研究提供了有关 CRD 的更多信息。此外，Pru p 7 是对桃子产生全身反应的危险因素，最近还发现它与柏树和日本杉树花粉有交叉反应。基于 CRD 的临床实践有很多好处，如提高诊断准确性和改善对个体患者的管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Allergy and Clinical Immunology 医学-过敏

CiteScore

5.90

自引率

3.60%

发文量

109

审稿时长

6-12 weeks

期刊介绍： This reader-friendly, bimonthly resource provides a powerful, broad-based perspective on the most important advances from throughout the world literature. Featuring renowned guest editors and focusing exclusively on one to three topics, every issue of Current Opinion in Allergy and Clinical Immunology delivers unvarnished, expert assessments of developments from the previous year. Insightful editorials and on-the-mark invited reviews cover key subjects such as upper airway disease; mechanisms of allergy and adult asthma; paediatric asthma and development of atopy; food and drug allergies; and immunotherapy.