Association of Bone Turnover Biomarkers and Subclinical Atherosclerosis in Subjects with Type 2 Diabetes: A Case-Control Study

IF 0.7 Q4 ENDOCRINOLOGY & METABOLISM

Clinical Diabetology Pub Date : 2024-03-01 DOI:10.5603/cd.98236

N. Lachine, Eman Y. Morsy, A. Elnekiedy, Mohamed A. Sadaka, G. I. Khalil, Hesham G. Imam, H. Kassab, Noha G. Amin

{"title":"Association of Bone Turnover Biomarkers and Subclinical Atherosclerosis in Subjects with Type 2 Diabetes: A Case-Control Study","authors":"N. Lachine, Eman Y. Morsy, A. Elnekiedy, Mohamed A. Sadaka, G. I. Khalil, Hesham G. Imam, H. Kassab, Noha G. Amin","doi":"10.5603/cd.98236","DOIUrl":null,"url":null,"abstract":"Objective: The current study aims to assess the relationship between serum osteocalcin (OCN) and osteoprotegerin (OPG) levels and subclinical atherosclerosis. Material and methods: This case-control study included 80 male subjects divided into 2 groups: 40 subjects with type 2 diabetes (T2D) without coronary artery disease and 40 control subjects without diabetes. To assess the association of OCN and OPG with subclinical atherosclerosis (defined as carotid intima-media thick - ness (cIMT) ≥ 0.9mm), multivariable linear regression models were applied. Results: The mean age in the diabetes group was 54.1 ± ± 5.1 years while in the control group, it was 53.7 ± ± 6.6 years. The mean serum OCN level was signifi - cantly negatively correlated with hs-CRP, cIMT, HbA1c and FPG in the total sample (p = 0.001, < 0.001, < 0.001 and 0.006 respectively) while OPG level was significantly positively correlated with age and HbA1c (p = 0.047 and 0.009 respectively) in the total sample. Age and HbA1c were the only independent risk factors identifying subclinical atherosclerosis in multivariate analysis. A cut-off value of serum OCN level of ≤ 22 ng/mL was able to discriminate patients with subclinical atherosclerosis in the total sample (p = 0.003 * ) using receiver operator characteristic (ROC) curve analysis. Serum OCN level was significantly lower in the subclini - cal atherosclerosis group than in the control while OPG showed no significant difference between both groups. Conclusions: OCN may be a better marker for subclinical atherosclerosis than OPG. This effect is attenuated in the presence of DM. (Clin Diabetol 2024; 13, 1: 43–51)","PeriodicalId":10386,"journal":{"name":"Clinical Diabetology","volume":null,"pages":null},"PeriodicalIF":0.7000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Diabetology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5603/cd.98236","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: The current study aims to assess the relationship between serum osteocalcin (OCN) and osteoprotegerin (OPG) levels and subclinical atherosclerosis. Material and methods: This case-control study included 80 male subjects divided into 2 groups: 40 subjects with type 2 diabetes (T2D) without coronary artery disease and 40 control subjects without diabetes. To assess the association of OCN and OPG with subclinical atherosclerosis (defined as carotid intima-media thick - ness (cIMT) ≥ 0.9mm), multivariable linear regression models were applied. Results: The mean age in the diabetes group was 54.1 ± ± 5.1 years while in the control group, it was 53.7 ± ± 6.6 years. The mean serum OCN level was signifi - cantly negatively correlated with hs-CRP, cIMT, HbA1c and FPG in the total sample (p = 0.001, < 0.001, < 0.001 and 0.006 respectively) while OPG level was significantly positively correlated with age and HbA1c (p = 0.047 and 0.009 respectively) in the total sample. Age and HbA1c were the only independent risk factors identifying subclinical atherosclerosis in multivariate analysis. A cut-off value of serum OCN level of ≤ 22 ng/mL was able to discriminate patients with subclinical atherosclerosis in the total sample (p = 0.003 * ) using receiver operator characteristic (ROC) curve analysis. Serum OCN level was significantly lower in the subclini - cal atherosclerosis group than in the control while OPG showed no significant difference between both groups. Conclusions: OCN may be a better marker for subclinical atherosclerosis than OPG. This effect is attenuated in the presence of DM. (Clin Diabetol 2024; 13, 1: 43–51)

查看原文本刊更多论文

2 型糖尿病患者骨转换生物标志物与亚临床动脉粥样硬化的关系：病例对照研究

研究目的本研究旨在评估血清骨钙素（OCN）和骨保护素（OPG）水平与亚临床动脉粥样硬化之间的关系。材料与方法这项病例对照研究纳入了 80 名男性受试者，分为两组：40 名无冠状动脉疾病的 2 型糖尿病（T2D）受试者和 40 名无糖尿病的对照受试者。为了评估 OCN 和 OPG 与亚临床动脉粥样硬化（定义为颈动脉内膜中层厚度（cIMT）≥ 0.9 毫米）的关系，采用了多变量线性回归模型。结果显示糖尿病组的平均年龄为（54.1 ± ± 5.1）岁，对照组为（53.7 ± ± 6.6）岁。在所有样本中，平均血清 OCN 水平与 hs-CRP、cIMT、HbA1c 和 FPG 呈显著负相关（分别为 p = 0.001、< 0.001、< 0.001 和 0.006），而 OPG 水平与年龄和 HbA1c 呈显著正相关（分别为 p = 0.047 和 0.009）。在多变量分析中，年龄和 HbA1c 是识别亚临床动脉粥样硬化的唯一独立风险因素。通过接收器操作特征曲线（ROC）分析，血清 OCN 水平≤ 22 纳克/毫升的临界值能够区分总样本中的亚临床动脉粥样硬化患者（p = 0.003 * ）。亚临床动脉粥样硬化组的血清 OCN 水平明显低于对照组，而 OPG 在两组间无明显差异。结论：OCN与 OPG 相比，OCN 可能是亚临床动脉粥样硬化的更好标记物。如果存在糖尿病，这种效果会减弱。(Clin Diabetol 2024; 13, 1: 43-51)

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical Diabetology ENDOCRINOLOGY & METABOLISM-

CiteScore

0.90

自引率

14.30%

发文量

审稿时长

25 weeks

期刊介绍： Clinical Diabetology hereinafter referred to as ‘CD’ or ′the Journal′, is a peer-reviewed, open access journal covering broad spectrum of topics in diabetology and aiming to advance the knowledge and science of this rapidly evolving field. The Journal is the official bimonthly of the Diabetes Poland (Polish Diabetes Association) and publishes review articles, original clinical and experimental investigations in the field of diabetology, case reports, letters and editorial comments . The Journal has been published in full text English since 2016.