Coinfection of malaria and scrub typhus in a toddler: First report from South India

Nandini Vasudevan, Sawantharia Jaganathan, Priya Jose, P. Kommu
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引用次数: 0

Abstract

Tropical infections are common in South Asia, including India. However, coinfections among the different diseases are rare in children. We report a case of malaria-scrub typhus coinfection in a toddler from South India. A 3-year-old boy presented with fever. He was pale, dull-looking and had hepatosplenomegaly.. There was mild leukocytosis with positive C reactive protein. Rapid malarial antigen was positive, and started on antimalarial therapy. Fever was persisting after 48 h and doxycycline was started. Scrub typhus immunoglobulin M was positive. He responded dramatically to doxycycline, and in 24 hours, he became afebrile. The prevalence of this coinfection was studied by Wilairatana et al. in 2021 and showed a low prevalence of 0%–1%. Our case is unique and rare as this has not been reported in a toddler. Children with acute undifferentiated fever which is not responding to therapy within 48 hours must be investigated for concurrent infection.
一名幼儿同时感染疟疾和恙虫病:南印度的首次报告
热带传染病在包括印度在内的南亚地区很常见。然而,儿童同时感染不同疾病的情况却很少见。我们报告了一例南印度幼儿同时感染疟疾和恙虫病的病例。一名 3 岁男孩因发烧前来就诊。他面色苍白,神情呆滞,肝脾肿大。白细胞轻度增多,C 反应蛋白呈阳性。快速疟疾抗原呈阳性,开始接受抗疟疾治疗。48 小时后持续发热,开始使用强力霉素。恙虫病免疫球蛋白 M 呈阳性。他对强力霉素的反应非常明显,24 小时后就转为无热。Wilairatana 等人在 2021 年对这种合并感染的发病率进行了研究,结果显示发病率较低,仅为 0%-1%。我们的病例很独特,也很罕见,因为在幼儿中还没有报道过。对于在 48 小时内对治疗无反应的急性未分化发热患儿,必须对并发感染进行调查。
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20 weeks
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