Estimation of Pro-Inflammatory Markers In Night Shift Healthcare Workers And Identify Risk Factors Associated With It

Jyotirmayee Bahinipati, Baibhav Agrawal, RajLaxmi Sarangi, RG Asutosh Mohapatra, Mona Pathak, Srikrushna Mahapatra, S. R. Mohapatra
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Abstract

Shift labor, with hours outside of the regular diurnal work cycle, is used to facilitate round-the-clock emergency healthcare services. This impacts the circadian rhythm, which can potentially activate the pro-inflammatory responses of the immune system. This study aimed to find out the levels of pro-inflammatory markers in night shift healthcare workers and find risk factors associated with their increase. 303 participants (doctors, nurses, technicians, health care aids) were recruited with 169 participants nightshift and 134 dayshift workers. Pro-inflammatory markers Highly Sensitive C-Reactive Protein (hsCRP) and Total Leukocyte Count (TLC)] were estimated. Factors were compared by t test, Wilcoxon Rank Sum test and Chi square test. Risk factors for hsCRP elevation were identified by logistic regression analysis. Pro-inflammatory markers like hsCRP and TLC were significantly increased in night shift health workers in comparison to the day shift workers (hsCRP 0.30± 0.33 mg/dl vs 0.10± 0.09 mg/dl, TLC 8181.06± 1181.53 /cu mm vs 7473.80± 1018.81 /cu mm) respectively. Multivariate logistic regression analysis showed night shift work (OR 48.20 95% CI (4.99-465.61), age (OR 1.13 95% CI (1.01-1.26)) and BMI (OR 1.18 95% CI (1.06-1.32)) as independent predictors of elevated hsCRP after adjusting for other risk factors. Hence, night-shift work is an independent risk factor for a rise in pro-inflammatory markers. These findings might aid health care workers and policymakers strategize methods to tackle the challenges through providing support programs, counselling sessions to avoid ailments and deliver health services in a better way.
估算夜班医护人员的促炎标记物并确定相关风险因素
轮班工作的时间不在正常的昼夜工作周期内,是为了方便提供全天候的紧急医疗服务。这影响了昼夜节律,有可能激活免疫系统的促炎反应。这项研究旨在了解夜班医护人员的促炎症指标水平,并找出与指标升高相关的风险因素。研究共招募了 303 名参与者(医生、护士、技师、医护人员),其中夜班 169 人,日班 134 人。对前炎标志物高敏 C 反应蛋白(hsCRP)和白细胞总数(TLC)进行了估计。通过 t 检验、Wilcoxon Rank Sum 检验和 Chi Square 检验对各因素进行比较。与白班工人相比,夜班工人的前炎症指标如 hsCRP 和 TLC 显著增加(hsCRP 0.30± 0.33 mg/dl vs 0.10± 0.09 mg/dl,TLC 8181.06± 1181.53 /cu mm vs 7473.80± 1018.81 /cu mm)。多变量逻辑回归分析显示,在调整其他风险因素后,夜班工作(OR 48.20 95% CI (4.99-465.61))、年龄(OR 1.13 95% CI (1.01-1.26))和体重指数(OR 1.18 95% CI (1.06-1.32))是 hsCRP 升高的独立预测因素。因此,夜班工作是促炎标志物升高的一个独立风险因素。这些发现可能有助于医护人员和政策制定者制定策略,通过提供支持计划和辅导课程来避免疾病,并以更好的方式提供医疗服务,从而应对挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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