The role of the microenvironment in tumor growth and spreading

Q3 Medicine

Obstetrics, Gynecology and Reproduction Pub Date : 2024-03-06 DOI:10.17749/2313-7347/ob.gyn.rep.2024.489

V. Bitsadze, Е. V. Slukhanchuk, А. Solopova, J. Khizroeva, F. Yakubova, Е. А. Orudzhova, N. Degtyareva, Е. S. Egorova, N. А. Makatsariya, N. Samburova, V. N. Serov, L. Ashrafyan, Z. G. Aslanova, А. V. Lazarchuk, Е. S. Kudryavtseva, А. Е. Solopova, D. L. Kapanadze, J.-С. Gris, I. Elalamy, С. Ay, А. D. Makatsariya

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Abstract

Introduction. The tumor microenvironment (TME) consisting of non-tumor cells and other components plays a crucial role in cancer development by promoting uncontrolled tumor growth.Aim: to detail all the components in TME and their contribution to carcinogenesis by analyzing available publications.Results. Currently, TME study is of great interest in the medical field. Its crucial role in the tumor initiation, progression, and spreading is emphasized. Several constituents have been identified in TME including cancer-associated fibroblasts, neutrophils, adipocytes, tumor vasculature, lymphocytes, extracellular matrix, dendritic cells, neutrophil extracellular traps, etc. Thromboinflammatory reactions are also considered an important TME element.Conclusion. TME constituents can serve as new targets for both diagnostics and antitumor therapy.

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微环境在肿瘤生长和扩散中的作用

导言。肿瘤微环境（TME）由非肿瘤细胞和其他成分组成，通过促进肿瘤不受控制的生长，在癌症发展过程中发挥着至关重要的作用。目前，TME 研究在医学领域备受关注。它在肿瘤发生、发展和扩散过程中的关键作用受到重视。目前已发现 TME 中有多种成分，包括癌症相关成纤维细胞、中性粒细胞、脂肪细胞、肿瘤血管、淋巴细胞、细胞外基质、树突状细胞、中性粒细胞胞外捕获器等。血栓炎症反应也被认为是TME的重要组成部分。TME成分可作为诊断和抗肿瘤治疗的新靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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