Efficacy of combination therapy 5% permethrin cream and precipitated sulfur (ointment 2-4) compared with single therapy of 5% permethrin cream in children

Pub Date : 2024-03-08 DOI:10.15562/bmj.v13i1.5285

Frizka Eliza, M. Listiawan, Sawitri, Cita Rosita, Sigit Prakoeswa, Evy Ervianti, Budi Utomo, Erik Rizka Yulianggoro, Muhammad Yulianto, Listiawan

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Abstract

Introduction: Scabies is a skin infestation with the main pruritus symptom caused by Sarcoptes scabiei. The common complaints are discomfort due to itching and a picture of lesions on the skin in the form of papules, pustules, or vesicles. The study aims to analyze the comparative efficacy of using a combination therapy of 5% permethrin cream and precipitated sulfur (ointment 2-4) compared with single therapy of 5% permethrin cream in pediatric scabies patients at the Outpatient Clinic Dr. Soetomo General Academic Hospital in the 2019-2020 period. Methods: This study is an analytical study using a cross-sectional retrospective method, which aims to compare the effectiveness of using a combination of 5% permethrin cream and precipitated sulfur(ointment 2-4) compared to 5% permethrin cream as a single therapy. Study data were processed using SPSS, followed by univariate and bivariate analyses using statistical methods and comparative tests. Results: This study found 88 new scabies patients, with the number of patients who received permethrin single therapy as many as 43 patients (51.1%), while those who received combination therapy were 45 patients (48.9%). Scabies treatment using combination therapy has better effectiveness than single therapy 5% permethrin cream when seen from the absence of new complaints and improvement of skin lesions after receiving treatment. Analysis of therapy results for the emergence of new complaints with a p-value of 0.010 showed significant results. Analysis of the results of therapy seen in skin lesions improved on single therapy with a p-value of 0.014, indicating significant results. Conclusion: Significant results were found in the group that received combination therapy treatment seen from the improvement of skin lesions and no new lesions were found, while there were no significant comparison results when seen from complaints of itching

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儿童 5%氯菊酯乳膏和沉淀硫磺（2-4 号软膏）联合疗法与 5%氯菊酯乳膏单一疗法的疗效比较

简介疥疮是由疥螨引起的以瘙痒为主要症状的皮肤病。常见的主诉症状是瘙痒不适，皮肤上出现丘疹、脓疱或水泡状皮损。本研究旨在分析2019-2020年期间在土友博士综合学术医院门诊部对小儿疥疮患者使用5%氯菊酯乳膏和沉淀硫磺（2-4号软膏）联合疗法与5%氯菊酯乳膏单一疗法的疗效比较：本研究采用横断面回顾性分析方法，旨在比较5%氯菊酯乳膏和沉淀硫磺（软膏2-4）联合使用与5%氯菊酯乳膏单一治疗的效果。研究数据使用 SPSS 进行处理，然后使用统计方法和比较试验进行单变量和双变量分析：本研究发现了 88 例新的疥疮患者，其中接受氯菊酯单一疗法的患者多达 43 例（51.1%），而接受联合疗法的患者为 45 例（48.9%）。从接受治疗后没有新的主诉和皮损改善的情况来看，采用联合疗法治疗疥疮比单一疗法 5%氯菊酯乳膏的疗效更好。对出现新症状的治疗结果进行分析，P 值为 0.010，结果显示效果显著。对单次治疗后皮损改善的治疗结果进行分析，P 值为 0.014，显示效果显著：接受综合疗法治疗的组别在皮损改善和未发现新皮损方面取得了显著效果，而在瘙痒主诉方面则没有明显的比较结果。

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