Bio-remedial Impact of Elaeocarpus sphaericus Seed Extract (ESSE) against Sodium Arsenite (As)-Induced Nephrotoxicity in Charles foster rats

Journal of Advanced Zoology Pub Date : 2024-03-11 DOI:10.53555//jaz.v45i3.3974

Prabhat Shankar, Rana Vikram Singh, Arun Kumar

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Abstract

The presence of arsenic (As) metalloid in groundwater poses serious threat to human and animal’s health. Approx. 300 million people of about 105 countries in the world are affected due to arsenite poisoning. Except mitigation there is no such mode by which the population can be prevented from being exposed to arsenic. Elaeocarpus sphaericus (E. sphaericus) is widely used in the folk medicine system for the treatment of various diseases. Hence, present study aimed to investigate the Bio-remedial Impact of ESSE against As-Induced Nephrotoxicity in Charles foster rats. Male twenty-four rats (weighing 160 ± 20 g) were randomly assigned into two groups, where Group-I (n=6) rats were used as control. Group-II (n=18) rats were treated with sodium arsenite at 8 mg/Kg body weight for 90 days daily and then further divided into three sub-groups. Sub-Group I (n=6); rats were sacrificed and data were collected, Sub-Group II (n=6); rats were left for 60 days for auto recovery (as As-pre-treated group), and Sub-Group II (n=6); rats were administrated with E. sphaericus at 20mg/kg body weight for 60 days. After the completion of entire experimental dose all the control and treatment group were sacrificed to evaluate the various parameters. As-Induced rats had Significant (p<0.0001) alteration in haematological parameters. As-Induced serum levels of urea, uric acid, creatinine and albumin had significant (p<0.0001) alteration. Level of MDA and BUN were significantly (p<0001) increased. However, ESSE administration significantly reduced the adverse effect related to test of nephrological functions, MDA level significantly (p<0.0001) reduced. Dose dependent ESSE administration combat As-Induced toxicity and significantly (P<0.0001) normalise the level of haematological parameters. Hence, the study concluded that E. sphaericus seed might be used as a nutritional supplement to combat the arsenic led toxicity among the exposed population.

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皂荚籽提取物（ESSE）对亚砷酸钠（As）诱导的查尔斯寄养大鼠肾毒性的生物补救影响

地下水中金属砷（As）的存在对人类和动物的健康构成严重威胁。全世界约有 105 个国家的约 3 亿人受到亚砷酸盐中毒的影响。除了采取缓解措施外，没有其他方法可以防止人们接触砷。Elaeocarpus sphaericus（E. sphaericus）在民间医药系统中被广泛用于治疗各种疾病。因此，本研究旨在调查皂荚对查尔斯寄养大鼠砷诱发的肾毒性的生物补救影响。将 24 只雄性大鼠（体重 160 ± 20 克）随机分为两组，其中第一组（n=6）作为对照组。第二组（n=18）大鼠每天用 8 毫克/千克体重的亚砷酸钠治疗 90 天，然后再分成三个亚组。子组 I（n=6）：大鼠被处死并收集数据；子组 II（n=6）：大鼠被放置 60 天进行自我恢复（作为砷预处理组）；子组 II（n=6）：大鼠被注射 20 毫克/千克体重的 E. sphaericus 60 天。在完成整个实验剂量后，所有对照组和治疗组均被处死，以评估各种参数。药物诱导组大鼠的血液学参数发生了显著变化（p<0.0001）。诱导组血清中的尿素、尿酸、肌酐和白蛋白水平有显著变化（p<0.0001）。MDA 和 BUN 水平明显升高（p<0001）。然而，服用易瑞沙可明显降低与肾功能测试有关的不良反应，MDA 水平明显降低（p<0.0001）。剂量依赖性 ESSE 给药能对抗 As 诱导的毒性，并能显著（P<0.0001）使血液学参数水平恢复正常。因此，该研究得出结论，辣木籽可用作营养补充剂，以对抗砷对暴露人群的毒性。

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Journal of Advanced Zoology

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