Ethyl-Iophenoxic acid as a serum marker for oral baiting of Tasmanian devils

IF 1 4区生物学 Q3 ZOOLOGY

Australian Journal of Zoology Pub Date : 2024-03-15 DOI:10.1071/zo23017

Ruth Pye, David S Nichols, Sally A. Nofs, Amy T. Gilbert, A. Flies

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引用次数: 0

Abstract

Oral baits containing vaccines, medicants or toxicants have been delivered to a broad range of wildlife species to protect against or treat disease, or suppress populations. Ethyl-Iophenoxic acid (Et-IPA) is used as a biomarker to determine oral bait consumption by wildlife species to assess and refine baiting strategies. Et-IPA is a persistent biomarker in many eutherian mammal species but not in the two marsupial species, swamp wallaby (Wallabia bicolor) and brushtail possum (Trichosurus vulpecula), tested to date. Et-IPA has not previously been evaluated in carnivorous marsupials. The Tasmanian devil (Sarcophilus harrisii), the largest extant carnivorous marsupial, is threatened by devil facial tumour disease (DFTD). Development of an oral DFTD vaccine bait is underway. In this study, eight devils were fed between 1 mg and 50 mg Et-IPA via oral baits to assess the effectiveness of Et-IPA as a serum biomarker for this species. Using liquid chromatography with tandem mass spectrometry, serum Et-IPA was detected in the devils up to 206 days after ingestion. This study demonstrates the utility of Et-IPA for estimating oral bait consumption by devils, the first carnivorous marsupial species to which this applies.

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作为塔斯马尼亚袋獾口服诱饵的血清标记物的乙基异苯氧酸

含有疫苗、药物或毒物的口服毒饵已被投放到多种野生动物体内，以预防或治疗疾病，或抑制种群数量。乙基异苯氧乙酸（Et-IPA）被用作一种生物标记物，用于确定野生动物物种的口服诱饵消耗量，以评估和改进诱饵投放策略。在许多有蹄类哺乳动物中，Et-IPA 是一种持久性生物标记物，但在迄今为止测试过的两种有袋类动物--沼泽袋鼠（Wallabia bicolor）和刷尾负鼠（Trichosurus vulpecula）中，Et-IPA 并非持久性生物标记物。Et-IPA 以前从未在食肉有袋类动物中进行过评估。塔斯马尼亚魔鬼（Sarcophilus harrisii）是现存最大的食肉有袋类动物，正受到魔鬼面部肿瘤病（DFTD）的威胁。目前正在开发一种口服 DFTD 疫苗诱饵。在这项研究中，通过口服诱饵给八只魔鬼喂食了1毫克到50毫克的Et-IPA，以评估Et-IPA作为该物种血清生物标记物的有效性。利用液相色谱-串联质谱法，在摄入后 206 天的魔鬼血清中检测到了 Et-IPA。这项研究证明了Et-IPA在估算魔鬼口腔饵料消耗量方面的实用性，魔鬼是第一个适用于Et-IPA的食肉有袋类动物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Australian Journal of Zoology 生物-动物学

CiteScore

2.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Australian Journal of Zoology is an international journal publishing contributions on evolutionary, molecular and comparative zoology. The journal focuses on Australasian fauna but also includes high-quality research from any region that has broader practical or theoretical relevance or that demonstrates a conceptual advance to any aspect of zoology. Subject areas include, but are not limited to: anatomy, physiology, molecular biology, genetics, reproductive biology, developmental biology, parasitology, morphology, behaviour, ecology, zoogeography, systematics and evolution. Australian Journal of Zoology is a valuable resource for professional zoologists, research scientists, resource managers, environmental consultants, students and amateurs interested in any aspect of the scientific study of animals. Australian Journal of Zoology is published with the endorsement of the Commonwealth Scientific and Industrial Research Organisation (CSIRO) and the Australian Academy of Science.