Optimizing Drug Delivery Vehicle with Multi-Criteria Decision Making (MCDM) - Based Excipient Selection

Q3 Pharmacology, Toxicology and Pharmaceutics

Jordan Journal of Pharmaceutical Sciences Pub Date : 2024-03-19 DOI:10.35516/jjps.v17i1.1692

I. Omoyayi, Süleyman Aşır, Abdullahi U. Ibrahim

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引用次数: 0

Abstract

Excipients are used in drug delivery systems as a means of effectively delivering drugs to their target site. Multi-criteria decision-making (MCDM) methods are tools for decision-making that consider multidimensional factors. Such methods are a comparative technology used in medicine that combines individual criteria into the total assessment of selected alternatives. This study aims to enhance the solubility and bioavailability of drugs through the application of MCDM-based excipient selection. By incorporating the Preference Ranking Organization Method for Enrichment Evaluations (PROMETHEE), various excipients can be evaluated and ranked based on their suitability for specific applications, considering parameters related to drug solubility and bioavailability. The results highlight the potential of cyclodextrins (net flow: 0.0023) and Eudragit polymers (net flow: 0.0016) as preferred options for drug carriers, while Poloxamer 188 (P188) (net flow: -0.0030) is identified as the least preferred option. This study demonstrates the effectiveness of the PROMETHEE method in improving the performance of poorly soluble and bioavailable drugs, ultimately contributing to the development of new drug delivery systems. The findings have significant implications for therapeutic outcomes in the treatment of diseases.

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基于多标准决策（MCDM）的辅料选择优化给药载体

药物输送系统中使用的辅料是将药物有效输送到目标部位的一种手段。多标准决策（MCDM）方法是考虑多维因素的决策工具。这种方法是一种用于医药领域的比较技术，它将单个标准与对所选替代品的总体评估相结合。本研究旨在通过应用基于 MCDM 的辅料选择来提高药物的溶解度和生物利用度。通过采用 "富集评价偏好排序组织法"（PROMETHEE），可以根据各种辅料在特定应用中的适用性对其进行评估和排序，同时考虑与药物溶解度和生物利用度相关的参数。结果表明，环糊精（净流量：0.0023）和 Eudragit 聚合物（净流量：0.0016）具有作为药物载体首选的潜力，而 Poloxamer 188 (P188)（净流量：-0.0030）被认为是最不可取的选择。这项研究证明了 PROMETHEE 方法在改善溶解性差、生物利用度低的药物性能方面的有效性，最终有助于新型药物输送系统的开发。研究结果对治疗疾病的疗效具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Jordan Journal of Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

1.70

自引率

0.00%

发文量

期刊介绍： The Jordan Journal of Pharmaceutical Sciences (JJPS) is a scientific, bi-annual, peer-reviewed publication that will focus on current topics of interest to the pharmaceutical community at large. Although the JJPS is intended to be of interest to pharmaceutical scientists, other healthy workers, and manufacturing processors will also find it most interesting and informative. Papers will cover basic pharmaceutical and applied research, scientific commentaries, as well as views, reviews. Topics on products will include manufacturing process, quality control, pharmaceutical engineering, pharmaceutical technology, and philosophies on all aspects of pharmaceutical sciences. The editorial advisory board would like to place an emphasis on new and innovative methods, technologies, and techniques for the pharmaceutical industry. The reader will find a broad range of important topics in this first issue.