No evidence of association between either Modic change or disc degeneration and five circulating inflammatory proteins

IF 3.4 3区 医学 Q1 ORTHOPEDICS
JOR Spine Pub Date : 2024-03-25 DOI:10.1002/jsp2.1323
Roger Compte, Maxim B. Freidin, Isabelle Granville Smith, Christine L. Le Maitre, Dovile Vaitkute, Ayrun Nessa, Genevieve Lachance, Frances M. K. Williams
{"title":"No evidence of association between either Modic change or disc degeneration and five circulating inflammatory proteins","authors":"Roger Compte,&nbsp;Maxim B. Freidin,&nbsp;Isabelle Granville Smith,&nbsp;Christine L. Le Maitre,&nbsp;Dovile Vaitkute,&nbsp;Ayrun Nessa,&nbsp;Genevieve Lachance,&nbsp;Frances M. K. Williams","doi":"10.1002/jsp2.1323","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Introduction</h3>\n \n <p>Intervertebral disc degeneration and Modic change are the main spinal structural changes associated with chronic low back pain (LBP). Both conditions are thought to manifest local inflammation and if inflammatory proteins translocate to the blood circulation could be detected systemically. The work here assesses whether the presence of disc degeneration is associated with detectable blood level changes of five inflammatory markers and whether chronic LBP is associated with these changes.</p>\n </section>\n \n <section>\n \n <h3> Materials and Methods</h3>\n \n <p>Two hundred and forty TwinsUK cohort participants with both MRI disc degeneration grade and Modic change extent, and IL-6, IL-8, IL-8 TNF, and CX3CL1 protein blood concentration measurements were included in this work. Linear mixed effects models were used to test the association of blood cytokine concentration with disc degeneration score and Modic change volumetric score. Association of chronic LBP status from questionnaires with disc degeneration, Modic change, and cytokine blood concentration was also tested.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>No statistically significant association between disc degeneration or Modic change with cytokine blood concentration was found. Instead, regression analysis pointed strong association between cytokine blood concentration with body mass index for IL-6 and with age for IL-6 and TNF. Mild association was found between IL-8 blood concentration and body mass index. Additionally, LBP status was associated with Modic change volumetric score but not associated with any cytokine concentration.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>We found no evidence that Modic change and disc degeneration are able to produce changes in tested blood cytokine concentration. However, age and body mass index have strong influence on cytokine concentration and both are associated with the conditions studied which may confound associations found in the literature. It is then unlikely that cytokines produced in the disc or vertebral bone marrow induce chronic LBP.</p>\n </section>\n </div>","PeriodicalId":14876,"journal":{"name":"JOR Spine","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jsp2.1323","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"JOR Spine","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jsp2.1323","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ORTHOPEDICS","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction

Intervertebral disc degeneration and Modic change are the main spinal structural changes associated with chronic low back pain (LBP). Both conditions are thought to manifest local inflammation and if inflammatory proteins translocate to the blood circulation could be detected systemically. The work here assesses whether the presence of disc degeneration is associated with detectable blood level changes of five inflammatory markers and whether chronic LBP is associated with these changes.

Materials and Methods

Two hundred and forty TwinsUK cohort participants with both MRI disc degeneration grade and Modic change extent, and IL-6, IL-8, IL-8 TNF, and CX3CL1 protein blood concentration measurements were included in this work. Linear mixed effects models were used to test the association of blood cytokine concentration with disc degeneration score and Modic change volumetric score. Association of chronic LBP status from questionnaires with disc degeneration, Modic change, and cytokine blood concentration was also tested.

Results

No statistically significant association between disc degeneration or Modic change with cytokine blood concentration was found. Instead, regression analysis pointed strong association between cytokine blood concentration with body mass index for IL-6 and with age for IL-6 and TNF. Mild association was found between IL-8 blood concentration and body mass index. Additionally, LBP status was associated with Modic change volumetric score but not associated with any cytokine concentration.

Conclusions

We found no evidence that Modic change and disc degeneration are able to produce changes in tested blood cytokine concentration. However, age and body mass index have strong influence on cytokine concentration and both are associated with the conditions studied which may confound associations found in the literature. It is then unlikely that cytokines produced in the disc or vertebral bone marrow induce chronic LBP.

Abstract Image

没有证据表明莫迪氏变化或椎间盘退变与五种循环炎症蛋白之间存在关联
导言椎间盘退变和莫迪病变是与慢性腰背痛(LBP)相关的主要脊柱结构变化。这两种情况都被认为表现为局部炎症,如果炎症蛋白转移到血液循环中,则可在全身进行检测。本研究评估了椎间盘退变是否与血液中可检测到的五种炎症标志物的水平变化有关,以及慢性腰背痛是否与这些变化有关。 材料和方法 240 名 TwinsUK 队列参与者均进行了 MRI 椎间盘退变等级和 Modic 变化程度以及 IL-6、IL-8、IL-8 TNF 和 CX3CL1 蛋白质血液浓度测量。线性混合效应模型用于检验血液细胞因子浓度与椎间盘退变评分和Modic变化体积评分之间的关系。此外,还测试了通过问卷调查得出的慢性跛行状态与椎间盘退变、Modic变化和细胞因子血液浓度之间的关系。 结果 没有发现椎间盘退变或 Modic 变化与细胞因子血液浓度之间有统计学意义的关联。相反,回归分析表明,细胞因子血液浓度与 IL-6 的体重指数以及 IL-6 和 TNF 的年龄有密切关系。IL-8的血液浓度与体重指数的关系不大。此外,枸杞多糖状态与莫迪克变化容积评分有关,但与任何细胞因子浓度无关。 结论 我们没有发现任何证据表明莫迪氏变化和椎间盘退变能够引起血液细胞因子浓度的变化。然而,年龄和体重指数对细胞因子浓度有很大影响,而且两者都与所研究的疾病有关,这可能会混淆文献中发现的关联。因此,椎间盘或脊椎骨骨髓中产生的细胞因子不太可能诱发慢性枸杞痛。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
JOR Spine
JOR Spine ORTHOPEDICS-
CiteScore
6.40
自引率
18.90%
发文量
42
审稿时长
10 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信