The Arg/Arg genotype of leptin receptor gene Gln223Arg polymorphism may be an independent risk factor for nonalcoholic fatty liver disease.

Laboratory medicine Pub Date : 2024-09-04 DOI:10.1093/labmed/lmae016

Mahsa Navari, Fatemeh Zarei, Shiva Sayedsalehi, Touraj Mahmoudi, Mitra Rostami, Aidin Mahban, Gholamreza Rezamand, Asadollah Asadi, Reza Dabiri, Hossein Nobakht, Hamid Farahani, Seidamir Pasha Tabaeian, Mohammad Reza Zali

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Abstract

Background: Given that obesity and insulin resistance play key roles in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and the connection between leptin and these metabolic diseases, the association between NAFLD and a leptin receptor gene (LEPR) polymorphism was examined.

Methods: In this genetic case-control association study, 144 biopsy-proven NAFLD patients and 144 controls were genotyped for the LEPR gene Gln223Arg (rs1137101) polymorphism using the polymerase chain reaction-restriction fragment length polymorphism method.

Results: The distributions of genotypes and alleles of Gln223Arg variant were in accordance with the Hardy-Weinberg equilibrium in the study groups (P > .05). Multivariate logistic regression analysis showed that the LEPR Gln223Arg Arg/Arg genotype was an independent risk factor for NAFLD; the Arg/Arg genotype, compared with the Gln/Gln genotype, was associated with a 2.09-fold increased risk for NAFLD (P = .036, odds ratio = 2.09 [95% CI = 1.31-5.95]).

Conclusions: We found that the LEPR Gln223Arg Arg/Arg genotype was independently associated with a more than 2-fold rise in biopsy-proven NAFLD risk. Our findings, however, need to be corroborated by further studies.

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瘦素受体基因 Gln223Arg 多态性的 Arg/Arg 基因型可能是非酒精性脂肪肝的独立风险因素。

背景：鉴于肥胖和胰岛素抵抗在非酒精性脂肪肝（NAFLD）的发病机制中起着关键作用，以及瘦素与这些代谢性疾病之间的联系，我们研究了非酒精性脂肪肝与瘦素受体基因（LEPR）多态性之间的关联：在这项基因病例对照关联研究中，采用聚合酶链式反应-限制性片段长度多态性方法对 144 名经活检证实的非酒精性脂肪肝患者和 144 名对照者进行了 LEPR 基因 Gln223Arg（rs1137101）多态性的基因分型：Gln223Arg变异的基因型和等位基因在研究组中的分布符合Hardy-Weinberg平衡（P > .05）。多变量逻辑回归分析表明，LEPR Gln223Arg Arg/Arg基因型是非酒精性脂肪肝的独立风险因素；与Gln/Gln基因型相比，Arg/Arg基因型与非酒精性脂肪肝风险增加2.09倍相关（P = .036，几率比 = 2.09 [95% CI = 1.31-5.95]）：我们发现，LEPR Gln223Arg Arg/Arg 基因型与活检证实的非酒精性脂肪肝风险增加 2 倍以上有独立关联。然而，我们的发现还需要进一步的研究来证实。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Laboratory medicine

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