Association of the IL1A and IL6 polymorphisms with posttraining changes in body mass, composition, and biochemical parameters in Caucasian women.

IF 4.2 2区 医学 Q1 SPORT SCIENCES
Biology of Sport Pub Date : 2024-03-01 Epub Date: 2023-09-21 DOI:10.5114/biolsport.2024.131415
Agata Leońska-Duniec, Weronika Lepionka, Andrzej Brodkiewicz, Maciej Buryta
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引用次数: 0

Abstract

Polymorphisms located in IL1A and IL6 are promising markers of obesity-related traits; however, studies concerning their potential impact on the effectiveness of lifestyle interventions are lacking. Therefore, the aim was to examine the association between the polymorphic sites located in IL1A (rs1800587) and IL6 (rs1800795, rs1800796, and rs1800797) and the body's response to a 12-week training program. We studied the genotype distribution in a group of 168 Caucasian females in whom body mass and composition parameters, the lipid profile, and glucose levels were measured before and after the exercise period. Our results showed that carriers of the IL1A rs1800597 CC genotype exhibited a significant decrease in total body water (TBW) in response to training (p = 0.045). Additionally, carriers of the IL6 rs1800797 GG and GA genotypes demonstrated a posttraining decrease in body mass index (BMI) (p = 0.039). Haplotype analysis revealed that only rare haplotypes, namely, GGA, CGG and CCG (rs1800795, rs1800796, and rs1800797, respectively), were linked to changes in phenotype, yet assessing individual haplotype effects was not possible. Studies of the interactions between these genes showed that carrying the TC-GG genotype (rs1800587-rs1800795 and rs1800587-rs1800796) may be associated with greater posttraining decreases in fat mass percentage (%FM) and fat-free mass (FM). Carriers of the CC-CG genotype (rs1800587-rs1800795) had significantly greater changes in triglycerides (TGL) over the training period. Our study showed that the IL1A and IL6 genotypes, either individually, in haplotype, or in gene-gene combination, may modify training-induced changes in body mass, composition, glucose levels, and the lipid profile in healthy women.

白种女性 IL1A 和 IL6 多态性与训练后体重、成分和生化指标变化的关系。
IL1A和IL6的多态性是肥胖相关特征的有希望的标记物;然而,有关它们对生活方式干预效果的潜在影响的研究还很缺乏。因此,我们的目的是研究 IL1A(rs1800587)和 IL6(rs1800795、rs1800796 和 rs1800797)多态性位点与身体对 12 周训练计划的反应之间的关联。我们对一组 168 名高加索女性的基因型分布进行了研究,并在运动前后测量了她们的体重和成分参数、血脂状况和血糖水平。研究结果表明,IL1A rs1800597 CC 基因型携带者在训练中表现出身体总水分(TBW)的显著下降(p = 0.045)。此外,IL6 rs1800797 GG 和 GA 基因型携带者的体重指数(BMI)在训练后也有所下降(p = 0.039)。单倍型分析表明,只有罕见的单倍型,即 GGA、CGG 和 CCG(分别为 rs1800795、rs1800796 和 rs1800797)与表型变化有关,但无法评估单个单倍型的影响。对这些基因之间相互作用的研究表明,携带 TC-GG 基因型(rs1800587-rs1800795 和 rs1800587-rs1800796)可能与训练后脂肪量百分比(%FM)和无脂肪量(FM)的更大减少有关。CC-CG 基因型(rs1800587-rs1800795)携带者在训练期间甘油三酯(TGL)的变化明显更大。我们的研究表明,IL1A 和 IL6 基因型,无论是单独、单体型还是基因-基因组合,都可能改变训练诱导的健康女性体重、成分、血糖水平和血脂谱的变化。
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来源期刊
Biology of Sport
Biology of Sport 生物-运动科学
CiteScore
8.20
自引率
12.50%
发文量
113
审稿时长
>12 weeks
期刊介绍: Biology of Sport is the official journal of the Institute of Sport in Warsaw, Poland, published since 1984. Biology of Sport is an international scientific peer-reviewed journal, published quarterly in both paper and electronic format. The journal publishes articles concerning basic and applied sciences in sport: sports and exercise physiology, sports immunology and medicine, sports genetics, training and testing, pharmacology, as well as in other biological aspects related to sport. Priority is given to inter-disciplinary papers.
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