Clinical Experience on the Use of a Single-day, Two-injection Start Initiation Regimen of Aripiprazole Once Monthly in Patients With Schizophrenia in Spain: SaTISfy Study.

IF 1.3 4区 医学 Q3 PSYCHIATRY
Miquel Bioque, María José Moreno, Susana Gómez-Lus, María Isabel Ramos
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Abstract

Objective: The two-injection start (TIS) initiation regimen was recently approved for aripiprazole once monthly 400 mg (AOM400), with potential benefits in adherence. The SaTISfy study described in this article analyzed Spanish psychiatrists' perspectives on hospitalization lengths of stay, schizophrenia management, and the use of AOM400-TIS.

Methods: The authors describe an ecological study of aggregated data collected using a 41-question survey. Fifty psychiatrists were asked to provide their perceptions of their patients with schizophrenia and treatment with AOM400.

Results: The psychiatrists reported that lack of treatment adherence was the main reason for hospitalization for 58.3% of their patients diagnosed with schizophrenia. Aripiprazole, in any formulation, was the most commonly prescribed therapeutic option, being prescribed for a mean (SD) of 2.5 (0.9) out of 5 patients, while 98% of psychiatrists chose AOM400-TIS for patients who failed to adhere to previous treatments. Patients with schizophrenia, regardless of their treatment, were hospitalized for an average of 17.7 (3.93) days versus patients with schizophrenia treated with AOM400-TIS, who were hospitalized for an average of 14.2 (4.18) days, a reduction of 3.5 (3.86) days. Patients treated with AOM400-TIS showed a reduction of 5 (4.18) days compared with the mean national duration of hospitalization for acute patients in psychiatry units in Spain (19.18 d). The surveyed psychiatrists reported that AOM400-TIS improved safety and tolerability. Most of the psychiatrists were satisfied with the administration and results of AOM400-TIS. Most of the psychiatrists (90%) also reported that fewer health care resources were consumed with AOM400-TIS, mainly due to a reduction in hospitalization days and in the use of concomitant medications.

Conclusions: AOM400-TIS was considered to have a positive impact on the duration of hospitalization and thus on the use of health care resources. There was a positive perception of adherence, safety, and tolerability with the use of AOM400-TIS in patients with schizophrenia.

西班牙精神分裂症患者使用阿立哌唑单日两次注射起始方案(每月一次)的临床经验:SaTISfy 研究。
目的:阿立哌唑每月注射一次,每次 400 毫克(AOM400),最近被批准采用两次注射起始(TIS)方案,这可能对患者的依从性有好处。本文所述的 SaTISfy 研究分析了西班牙精神科医生对住院时间、精神分裂症管理和 AOM400-TIS 使用情况的看法:作者介绍了一项通过 41 个问题的调查收集汇总数据的生态研究。50名精神科医生被要求提供他们对精神分裂症患者和AOM400治疗的看法:结果:精神科医生表示,在他们诊断出的精神分裂症患者中,58.3%的患者住院的主要原因是缺乏治疗依从性。阿立哌唑(任何剂型)是最常见的处方治疗方案,平均(标清)5名患者中有2.5名(0.9名)接受了阿立哌唑的治疗,而98%的精神科医生选择AOM400-TIS来治疗之前未能坚持治疗的患者。接受AOM400-TIS治疗的精神分裂症患者平均住院17.7(3.93)天,而接受AOM400-TIS治疗的精神分裂症患者平均住院14.2(4.18)天,缩短了3.5(3.86)天。与西班牙全国精神科急症患者的平均住院时间(19.18 天)相比,接受 AOM400-TIS 治疗的患者的住院时间缩短了 5 (4.18) 天。接受调查的精神科医生表示,AOM400-TIS提高了安全性和耐受性。大多数精神科医生对 AOM400-TIS 的使用和效果表示满意。大多数精神科医生(90%)还表示,AOM400-TIS减少了医疗资源的消耗,主要原因是住院天数和同时使用的药物减少了:结论:AOM400-TIS被认为对住院时间有积极影响,因此对医疗资源的使用也有积极影响。精神分裂症患者对使用AOM400-TIS的依从性、安全性和耐受性有积极的看法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.30
自引率
10.50%
发文量
159
审稿时长
>12 weeks
期刊介绍: Journal of Psychiatric Practice® seizes the day with its emphasis on the three Rs — readability, reliability, and relevance. Featuring an eye-catching style, the journal combines clinically applicable reviews, case studies, and articles on treatment advances with practical and informative tips for treating patients. Mental health professionals will want access to this review journal — for sharpening their clinical skills, discovering the best in treatment, and navigating this rapidly changing field. Journal of Psychiatric Practice combines clinically applicable reviews, case studies, and articles on treatment advances with informative "how to" tips for surviving in a managed care environment.
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