A comprehensive review uncovering the anticancerous potential of genkwanin (plant-derived compound) in several human carcinomas

IF 2.1 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Open Chemistry Pub Date : 2024-03-21 DOI:10.1515/chem-2024-0003

Pratibha Pandey, Seema Ramniwas, Meenakshi Verma, Indra Rautela, Fahad Khan, Mohd Asif Shah

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引用次数: 0

Abstract

Plant-derived bioactive compounds displayed major therapeutic and chemo-preventive roles in the pathogenesis of numerous chronic malignancies such as cancer and enhanced oxidative stress and inflammation. Antioxidants found in food, such as genkwanin, may reduce oxidative stress and the release of cytokines or pathways that promote inflammation. The goal of this work is to summarize the potential for anticancer effects of genkwanin, a methoxyflavone that is present in a variety of plant species. This review examined and analyzed numerous research studies on identifying, isolating, measuring, and analyzing anticancer properties of genkwanin. The mechanisms involved cellular and molecular activities at various levels, including apoptosis induction and cancer cell growth and proliferation inhibition. Preclinical studies have demonstrated genkwanin’s effects and mechanism of action; however, further research is required to investigate its therapeutic potential thoroughly. Additional research is needed to further our understanding of the pharmacodynamic effects of genkwanin. Additional toxicological study is necessary to evaluate the clinical efficacy and safety of genkwanin, which would help scientists to elucidate a potent drug candidate for cancer management.

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揭示玄参素（植物提取化合物）在几种人类癌症中抗癌潜力的全面综述

植物提取的生物活性化合物在许多慢性恶性肿瘤（如癌症）的发病机制中发挥着重要的治疗和化学预防作用，并能增强氧化应激和炎症反应。食物中的抗氧化剂，如玄参素，可减少氧化应激和细胞因子的释放或促进炎症的途径。本研究的目的是总结玄参素的潜在抗癌作用，玄参素是一种甲氧基黄酮，存在于多种植物物种中。这篇综述考察并分析了大量关于识别、分离、测量和分析玄葵素抗癌特性的研究。研究机制涉及不同层面的细胞和分子活动，包括诱导细胞凋亡和抑制癌细胞生长和增殖。临床前研究已经证明了 genkwanin 的效果和作用机制，但要彻底研究其治疗潜力，还需要进一步的研究。还需要进行更多的研究，以进一步了解 genkwanin 的药效学效应。还需要进行更多的毒理学研究，以评估 genkwanin 的临床疗效和安全性，这将有助于科学家阐明一种治疗癌症的有效候选药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

3.80

自引率

4.30%

发文量

审稿时长

6 weeks

期刊介绍： Open Chemistry is a peer-reviewed, open access journal that publishes original research, reviews and short communications in the fields of chemistry in an ongoing way. The central goal is to provide a hub for researchers working across all subjects to present their discoveries, and to be a forum for the discussion of the important issues in the field. The journal is the premier source for cutting edge research in fundamental chemistry and it provides high quality peer review services for its authors across the world. Moreover, it allows for libraries everywhere to avoid subscribing to multiple local publications, and to receive instead all the necessary chemistry research from a single source available to the entire scientific community.