Costs attributable to hypercholesterolemia in a single period and over the life cycle.

IF 3.1 3区 医学 Q1 ECONOMICS
European Journal of Health Economics Pub Date : 2024-12-01 Epub Date: 2024-03-22 DOI:10.1007/s10198-024-01684-0
Stephanie Reitzinger, Miriam Reiss, Thomas Czypionka
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Abstract

Hypercholesterolemia is a major risk factor for atherosclerotic cardiovascular disease leading to reduced (healthy) life years. The aim of this study is to quantify the societal costs associated with hypercholesterolemia. We use epidemiologic data on the distribution of cholesterol levels as well as data on relative risks regarding ischemic heart disease, stroke, and other cardiovascular diseases. The analytical approach is based on the use of population-attributable fractions applied to direct medical, direct non-medical and indirect costs using data of Austria. Within a life-cycle analysis we sum up the costs of hypercholesterolemia for the population of 2019 and, thus, consider future morbidity and mortality effects on this population. Epidemiologic data suggest that approximately half of Austria's population have low-density lipoprotein cholesterol (LDL-C) levels above the target levels (i.e., are exposed to increased risk). We estimate that 8.2% of deaths are attributable to hypercholesterolemia. Total costs amount to about 0.33% of GDP in the single-period view. In the life-cycle perspective, total costs amount to €806.06 million, €312.1 million of which are medical costs, and about €494 million arise due to production loss associated with hypercholesterolemia. The study points out that significant shares of deaths, entries into disability pension and care allowance, full-time equivalents lost to the labor market as well as monetary costs for the health system and the society could be avoided if LDL-C-levels of the population were reduced.

Abstract Image

高胆固醇血症在单个时期和整个生命周期的成本。
高胆固醇血症是动脉粥样硬化性心血管疾病的主要风险因素,会导致(健康)寿命减少。本研究旨在量化与高胆固醇血症相关的社会成本。我们使用了胆固醇水平分布的流行病学数据以及缺血性心脏病、中风和其他心血管疾病的相对风险数据。分析方法是利用奥地利的数据,将人口可归因分数应用于直接医疗、直接非医疗和间接成本。在生命周期分析中,我们总结了高胆固醇血症给 2019 年人口带来的成本,从而考虑了未来发病率和死亡率对这一人口的影响。流行病学数据表明,奥地利约有一半人口的低密度脂蛋白胆固醇(LDL-C)水平高于目标水平(即风险增加)。我们估计,8.2% 的死亡可归因于高胆固醇血症。从单期角度看,总成本约占国内生产总值的 0.33%。从生命周期的角度来看,总成本为 8.0606 亿欧元,其中 3.121 亿欧元为医疗成本,约 4.94 亿欧元为与高胆固醇血症相关的生产损失。研究指出,如果降低人口的低密度脂蛋白胆固醇水平,就可以避免大量死亡、领取伤残抚恤金和护理津贴、丧失相当于全职的劳动力以及卫生系统和社会的货币成本。
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来源期刊
CiteScore
6.10
自引率
2.30%
发文量
131
期刊介绍: The European Journal of Health Economics is a journal of Health Economics and associated disciplines. The growing demand for health economics and the introduction of new guidelines in various European countries were the motivation to generate a highly scientific and at the same time practice oriented journal considering the requirements of various health care systems in Europe. The international scientific board of opinion leaders guarantees high-quality, peer-reviewed publications as well as articles for pragmatic approaches in the field of health economics. We intend to cover all aspects of health economics: • Basics of health economic approaches and methods • Pharmacoeconomics • Health Care Systems • Pricing and Reimbursement Systems • Quality-of-Life-Studies The editors reserve the right to reject manuscripts that do not comply with the above-mentioned requirements. The author will be held responsible for false statements or for failure to fulfill the above-mentioned requirements. Officially cited as: Eur J Health Econ
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