Local Treatment of Children Suffering From Parameningeal Rhabdomyosarcoma: A Retrospective Single-Center Study From China.

IF 2.5 4区医学 Q3 ONCOLOGY

Cancer Control Pub Date : 2024-01-01 DOI:10.1177/10732748241240655

Xiaomin Peng, Xilin Xiong, Yang Li, Chunmou Li, Zhixuan Wang, Yu Wu, Mingwei Su, Wenjun Weng, Ke Huang, Dunhua Zhou, Jianpei Fang

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引用次数: 0

Abstract

Background: Treatment for parameningeal rhabdomyosarcoma (PM-RMS) has been a challenge since local control is difficult. The goal of this study was to analyse the impact of different local treatment approaches on childhood PM-RMS patients and help dispel the doubt that whether secondary radical surgery (SRS) should be encouraged in the management of PM-RMS.

Methods: A total of 17 children with PM-RMS who received unified systemic chemotherapy and individualized local therapy such as radiotherapy (RT) and/or SRS were included in this retrospective study. The overall survival (OS) and event free survival (EFS) were compared between groups adopting different local strategies.

Results: The 3-year OS and EFS of our PM-RMS patients was 75.5% and 56.5% respectively. The OS and EFS of patients who received SRS were both significantly lower than that of the non-SRS group (3-year OS: 50.0% vs 90.0%, P = .031; 3-year EFS: 33.3% vs 60.6%, P = .020). The OS and EFS of the patients who received RT was higher than that of the patients of the non-RT group (3-year OS: 85.6% vs 0%, P = .001; 3-year EFS: 64.0% vs 0%, P = .011).

Conclusion: This study illustrates that SRS was associated with poor prognosis of PM-RMS and should not be routinely performed. Optimized RT strategies along with more intensive chemotherapy may be alternative options to improve the survival of patients with PM-RMS. Multi-center, large sample and prospective studies are needed to further validate these findings.

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副脑膜横纹肌肉瘤患儿的局部治疗：中国单中心回顾性研究

背景：脑膜旁横纹肌肉瘤（PM-RMS）的治疗一直是一项挑战，因为局部控制非常困难。本研究旨在分析不同局部治疗方法对儿童PM-RMS患者的影响，帮助消除在治疗PM-RMS时是否应鼓励二次根治手术（SRS）的疑虑：这项回顾性研究共纳入了17名接受过统一的全身化疗和放疗（RT）和/或SRS等个体化局部治疗的PM-RMS患儿。比较了采用不同局部治疗策略组的总生存期（OS）和无事件生存期（EFS）：结果：PM-RMS患者的3年OS和EFS分别为75.5%和56.5%。接受SRS治疗的患者的OS和EFS均明显低于非SRS组（3年OS：50.0% vs 90.0%，P = .031；3年EFS：33.3% vs 60.6%，P = .020）。接受RT治疗的患者的OS和EFS均高于非RT组患者（3年OS：85.6% vs 0%，P = .001；3年EFS：64.0% vs 0%，P = .011）：本研究表明，SRS与PM-RMS的不良预后有关，不应常规实施。优化的 RT 策略和更强化的化疗可能是改善 PM-RMS 患者生存率的替代选择。需要进行多中心、大样本和前瞻性研究来进一步验证这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Control ONCOLOGY-

CiteScore

3.80

自引率

0.00%

发文量

148

审稿时长

>12 weeks

期刊介绍： Cancer Control is a JCR-ranked, peer-reviewed open access journal whose mission is to advance the prevention, detection, diagnosis, treatment, and palliative care of cancer by enabling researchers, doctors, policymakers, and other healthcare professionals to freely share research along the cancer control continuum. Our vision is a world where gold-standard cancer care is the norm, not the exception.