[Modification of orocecal transit time of salazosulfapyridine by atropine and metoclopramide in healthy probands].

Abstract

The first appearance of sulpharyridine in plasma was investigated in nine healthy informed male volunteers. In a three way crossover design 6 g salazopyrin alone, together with metoclopramide (0.3 mg/kg i.m.) or atropine (0.01 mg/kg i.m.) were given. Sulphapyridine appears in the blood at the (means +/- S means) 6.2 h +/- 0.8 h (range: 3-11 h) in controls. Together with metoclopramide the first appearance is 3.6 h +/- 0.7 h (range: 2-8 h) and together with atropine these values are 8.1 +/- 0.8 h (range: 6-12 h). The differences are significant with p less than 0.05. The results show the pharmacological modification of motility in the gastrointestinal tract and in consequence the usefulness of salazopyridine to determine the transit time.