Sweeteners in Orodispersible Films: How Much is too Much?

IF 1.7 Q3 PHARMACOLOGY & PHARMACY

Drug Research Pub Date : 2024-04-01 Epub Date: 2024-03-20 DOI:10.1055/a-2266-2522

Ognjenka Rahić, Sabina Behrem, Amina Tucak-Smajić, Jasmina Hadžiabdić, Belma Imamović, Lamija Hindija, Merima Šahinović, Edina Vranić

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引用次数: 0

Abstract

Four natural sweeteners (sucrose, xylitol, fructose, and isomalt) were selected to examine the influence of their qualities and amounts on the characteristics of orodispersible films. Sodium carboxymethylcellulose (2% w/w) was utilized as the film-forming polymer and 1% w/w glycerol as a plasticizer. Films were produced through the solvent casting method, rendering them suitable for convenient application in community or hospital pharmacy settings. The physicochemical and optical properties of the films were analyzed, and Fourier-transform infrared analysis was carried out. All films exhibited acceptable disintegration time, uniformity of mass, thickness, and optical characteristics, with significant dependence (p<0.05) on both sweetener type and quantity. Disintegration time varied based on the employed method, as well as the characteristics and amount of sweetener. Additionally, all films maintained pH values within the oral cavity range, suggesting no potential irritancy upon administration. Fourier-transform infrared analysis confirmed the formation of the film and demonstrated compatibility between its components.

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可发散薄膜中的甜味剂：多少才算多？

我们选择了四种天然甜味剂（蔗糖、木糖醇、果糖和异麦芽糖）来研究它们的质量和用量对口服可分散薄膜特性的影响。羧甲基纤维素钠（2% w/w）用作成膜聚合物，1% w/w 甘油用作增塑剂。薄膜通过溶剂浇铸法制成，适合在社区或医院药房方便使用。对薄膜的理化和光学特性进行了分析，并进行了傅立叶变换红外分析。所有薄膜都表现出可接受的崩解时间、质量均匀性、厚度和光学特性，且与药效有显著的相关性（p

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来源期刊

Drug Research PHARMACOLOGY & PHARMACY-

CiteScore

3.50

自引率

0.00%

发文量

期刊介绍： Drug Research (formerly Arzneimittelforschung) is an international peer-reviewed journal with expedited processing times presenting the very latest research results related to novel and established drug molecules and the evaluation of new drug development. A key focus of the publication is translational medicine and the application of biological discoveries in the development of drugs for use in the clinical environment. Articles and experimental data from across the field of drug research address not only the issue of drug discovery, but also the mathematical and statistical methods for evaluating results from industrial investigations and clinical trials. Publishing twelve times a year, Drug Research includes original research articles as well as reviews, commentaries and short communications in the following areas: analytics applied to clinical trials chemistry and biochemistry clinical and experimental pharmacology drug interactions efficacy testing pharmacodynamics pharmacokinetics teratology toxicology.