The causal relationship between sleep disturbances and the risk of frailty: a two-sample Mendelian randomization study.

IF 3.7 2区社会学 Q1 GERONTOLOGY

European Journal of Ageing Pub Date : 2024-03-19 DOI:10.1007/s10433-024-00804-2

Zong-Xiao Lu, Ni Sang, Rong-Chao Liu, Bo-Han Li, Meng-Yao Zhang, Ming-Hui Zhang, Meng-Cheng Cheng, Guo-Cui Wu

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引用次数: 0

Abstract

Objective: Adequate sleep is closely related to people's health. However, with increasing age, the quality of sleep worsens. At the same time, among elderly individuals, frailty is also a disturbing factor, which makes elderly individuals more vulnerable to negative factors. To explore the relationship between the two, we conducted this study.

Methods: In this paper, independent genetic variations related to insomnia, sleep duration and daytime sleepiness were selected as IVs, and related genetic tools were used to search published genome-wide association studies for a two-sample Mendelian randomization (TSMR) analysis. The inverse-variance weighted (IVW) method was used as the main Mendelian randomization analysis method. Cochran's Q test was used to test heterogeneity, MR‒Egger was used to test horizontal pleiotropy, and the MR-PRESSO test was used to remove outliers.

Results: According to our research, insomnia (OR = 1.10, 95% CI 1.03-1.17, P = 2.59e-97), long sleep duration (OR = 0.66, 95% CI 0.37-1.17, P = 0.02), short sleep duration (OR = 1.30, 95% CI 1.22-1.38, P = 2.23e-17) and daytime sleepiness (OR = 1.49, 95% CI 1.25-1.77, P = 0.96e-4) had a bidirectional causal relationship with frailty.

Conclusions: Our research showed that there is a causal relationship between sleep disturbances and frailty. This result was obtained by a TSMR analysis, which involves the use of genetic variation as an IV to determine causal relationships between exposure and outcome. Future TSMR studies should include a larger sample for analysis.

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睡眠障碍与虚弱风险之间的因果关系：双样本孟德尔随机研究。

目的充足的睡眠与人们的健康息息相关。然而，随着年龄的增长，睡眠质量会越来越差。同时，在老年人中，体弱也是一个令人不安的因素，这使得老年人更容易受到负面因素的影响。为了探索两者之间的关系，我们开展了这项研究：本文选取与失眠、睡眠时间和白天嗜睡相关的独立遗传变异作为IV，利用相关遗传学工具搜索已发表的全基因组关联研究，进行双样本孟德尔随机化（TSMR）分析。反方差加权（IVW）法是孟德尔随机分析的主要方法。Cochran的Q检验用于检验异质性，MR-Egger用于检验水平多义性，MR-PRESSO检验用于去除异常值：根据我们的研究，失眠（OR = 1.10，95% CI 1.03-1.17，P = 2.59e-97）、睡眠时间长（OR = 0.66，95% CI 0.37-1.17，P = 0.02）、睡眠时间短（OR = 1.30，95% CI 1.22-1.38，P = 2.23e-17）和白天嗜睡（OR = 1.49，95% CI 1.25-1.77，P = 0.96e-4）与虚弱有双向因果关系：我们的研究表明，睡眠障碍与体弱之间存在因果关系。这一结果是通过 TSMR 分析得出的，该分析将基因变异作为 IV 来确定暴露与结果之间的因果关系。未来的 TSMR 研究应纳入更多的样本进行分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Ageing GERONTOLOGY-

CiteScore

6.50

自引率

7.90%

发文量

期刊介绍： The European Journal of Ageing: Social, Behavioural and Health Perspectives is an interdisciplinary journal devoted to the understanding of ageing in European societies and the world over. EJA publishes original articles on the social, behavioral and population health aspects of ageing and encourages an integrated approach between these aspects. Emphasis is put on publishing empirical research (including meta-analyses), but conceptual papers (including narrative reviews) and methodological contributions will also be considered. EJA welcomes expert opinions on critical issues in ageing. By stimulating communication between researchers and those using research findings, it aims to contribute to the formulation of better policies and the development of better practice in serving older adults. To further specify, with the term ''social'' is meant the full scope of social science of ageing related research from the micro to the macro level of analysis. With the term ''behavioural'' the full scope of psychological ageing research including life span approaches based on a range of age groups from young to old is envisaged. The term ''population health-related'' denotes social-epidemiological and public health oriented research including research on functional health in the widest possible sense.