Healthy Lifestyle and the Risk of Metabolic Dysfunction-Associated Fatty Liver Disease: A Large Prospective Cohort Study.

IF 6.8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Diabetes & Metabolism Journal Pub Date : 2024-09-01 Epub Date: 2024-03-19 DOI:10.4093/dmj.2023.0133
Qing Chang, Yixiao Zhang, Tingjing Zhang, Zuyun Liu, Limin Cao, Qing Zhang, Li Liu, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Yang Ding, Yuhong Zhao, Kaijun Niu, Yang Xia
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Abstract

Backgruound: The incidence density of metabolic dysfunction-associated fatty liver disease (MAFLD) and the effect of a healthy lifestyle on the risk of MAFLD remain unknown. We evaluated the prevalence and incidence density of MAFLD and investigated the association between healthy lifestyle and the risk of MAFLD.

Methods: A cross-sectional analysis was conducted on 37,422 participants to explore the prevalence of MAFLD. A cohort analysis of 18,964 individuals was conducted to identify the incidence of MAFLD, as well as the association between healthy lifestyle and MAFLD. Cox proportional hazards regression was used to calculate the hazard ratio (HR) and 95% confidence interval (CI) with adjustments for confounding factors.

Results: The prevalence of MAFLD, non-alcoholic fatty liver disease, and their comorbidities were 30.38%, 28.09%, and 26.13%, respectively. After approximately 70 thousand person-years of follow-up, the incidence densities of the three conditions were 61.03, 55.49, and 51.64 per 1,000 person-years, respectively. Adherence to an overall healthy lifestyle was associated with a 19% decreased risk of MAFLD (HR, 0.81; 95% CI, 0.72 to 0.92), and the effects were modified by baseline age, sex, and body mass index (BMI). Subgroup analyses revealed that younger participants, men, and those with a lower BMI experienced more significant beneficial effects from healthy lifestyle.

Conclusion: Our results highlight the beneficial effect of adherence to a healthy lifestyle on the prevention of MAFLD. Health management for improving dietary intake, physical activity, and smoking and drinking habits are critical to improving MAFLD.

健康生活方式与代谢功能障碍相关性脂肪肝的风险:一项大型前瞻性队列研究。
背景:代谢功能障碍相关性脂肪肝(MAFLD)的发病密度以及健康生活方式对MAFLD风险的影响仍然未知。我们评估了代谢功能障碍相关性脂肪肝的患病率和发病密度,并研究了健康生活方式与代谢功能障碍相关性脂肪肝风险之间的关系:我们对 37,422 名参与者进行了横断面分析,以探讨 MAFLD 的患病率。对 18964 人进行了队列分析,以确定 MAFLD 的发病率以及健康生活方式与 MAFLD 之间的关联。在对混杂因素进行调整后,采用考克斯比例危险回归法计算危险比(HR)和95%置信区间(CI):结果:MAFLD、非酒精性脂肪肝及其合并症的患病率分别为 30.38%、28.09% 和 26.13%。经过约 7 万人年的随访,这三种疾病的发病密度分别为每千人年 61.03 例、55.49 例和 51.64 例。坚持总体健康的生活方式与 MAFLD 风险降低 19% 有关(HR,0.81;95% CI,0.72 至 0.92),其效果受基线年龄、性别和体重指数 (BMI) 的影响。分组分析表明,年轻参与者、男性和体重指数较低者从健康生活方式中获得的益处更为显著:我们的研究结果凸显了坚持健康生活方式对预防 MAFLD 的有益作用。改善饮食摄入、体育锻炼、吸烟和饮酒习惯的健康管理对改善 MAFLD 至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Diabetes & Metabolism Journal
Diabetes & Metabolism Journal Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
10.40
自引率
6.80%
发文量
92
审稿时长
52 weeks
期刊介绍: The aims of the Diabetes & Metabolism Journal are to contribute to the cure of and education about diabetes mellitus, and the advancement of diabetology through the sharing of scientific information on the latest developments in diabetology among members of the Korean Diabetes Association and other international societies. The Journal publishes articles on basic and clinical studies, focusing on areas such as metabolism, epidemiology, pathogenesis, complications, and treatments relevant to diabetes mellitus. It also publishes articles covering obesity and cardiovascular disease. Articles on translational research and timely issues including ubiquitous care or new technology in the management of diabetes and metabolic disorders are welcome. In addition, genome research, meta-analysis, and randomized controlled studies are welcome for publication. The editorial board invites articles from international research or clinical study groups. Publication is determined by the editors and peer reviewers, who are experts in their specific fields of diabetology.
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