Platelet Concentrates Preconditioning of Mesenchymal Stem Cells and Combined Therapies: Integrating Regenerative Strategies for Enhanced Clinical Applications.

IF 3.2 4区医学 Q3 CELL & TISSUE ENGINEERING

Cell Transplantation Pub Date : 2024-01-01 DOI:10.1177/09636897241235460

Xu-Huan Li, Han-Xi Xiao, Zu-Xiu Wang, Xin-Rong Tang, Xue-Feng Yu, Yong-Ping Pan

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引用次数: 0

Abstract

This article presents a comprehensive review of the factors influencing the efficacy of mesenchymal stem cells (MSCs) transplantation and its association with platelet concentrates (PCs). It focuses on investigating the impact of PCs' composition, the age and health status of platelet donors, application methods, and environmental factors on the outcomes of relevant treatments. In addition, it delves into the strategies and mechanisms for optimizing MSCs transplantation with PCs, encompassing preconditioning and combined therapies. Furthermore, it provides an in-depth exploration of the signaling pathways and proteomic characteristics associated with preconditioning and emphasizes the efficacy and specific effects of combined therapy. The article also introduces the latest advancements in the application of biomaterials for optimizing regenerative medical strategies, stimulating scholarly discourse on this subject. Through this comprehensive review, the primary goal is to facilitate a more profound comprehension of the factors influencing treatment outcomes, as well as the strategies and mechanisms for optimizing MSCs transplantation and the application of biomaterials in regenerative medicine, offering theoretical guidance and practical references for related research and clinical practice.

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血小板浓缩物预处理间充质干细胞和联合疗法：整合再生策略，加强临床应用。

本文全面综述了间充质干细胞（MSCs）移植疗效的影响因素及其与血小板浓缩物（PCs）的关联。文章重点研究了血小板浓缩物的成分、血小板捐献者的年龄和健康状况、应用方法和环境因素对相关治疗效果的影响。此外，它还深入探讨了利用 PCs 优化间充质干细胞移植的策略和机制，包括预处理和联合疗法。此外，文章还深入探讨了与预处理相关的信号通路和蛋白质组特征，并强调了联合疗法的疗效和特殊作用。文章还介绍了应用生物材料优化再生医疗策略的最新进展，激发了学术界对这一主题的讨论。通过这篇综述，主要目的是促进人们更深刻地理解影响治疗效果的因素，以及优化间充质干细胞移植和生物材料在再生医学中应用的策略和机制，为相关研究和临床实践提供理论指导和实践参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Transplantation 生物-细胞与组织工程

CiteScore

6.00

自引率

3.00%

发文量

审稿时长

6 months

期刊介绍： Cell Transplantation, The Regenerative Medicine Journal is an open access, peer reviewed journal that is published 12 times annually. Cell Transplantation is a multi-disciplinary forum for publication of articles on cell transplantation and its applications to human diseases. Articles focus on a myriad of topics including the physiological, medical, pre-clinical, tissue engineering, stem cell, and device-oriented aspects of the nervous, endocrine, cardiovascular, and endothelial systems, as well as genetically engineered cells. Cell Transplantation also reports on relevant technological advances, clinical studies, and regulatory considerations related to the implantation of cells into the body in order to provide complete coverage of the field.