Immunotherapy and Radiotherapy Combinations for Sarcoma

IF 2.6 3区医学 Q3 ONCOLOGY

Seminars in Radiation Oncology Pub Date : 2024-03-18 DOI:10.1016/j.semradonc.2023.12.005

Qian S. Zhang , John P. Hayes , Vinai Gondi , Seth M. Pollack

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引用次数: 0

Abstract

Sarcomas are a heterogeneous group of bone and soft tissue tumors. Survival outcomes for advanced (unresectable or metastatic) disease remain poor, so therapeutic improvements are needed. Radiotherapy plays an integral role in the neoadjuvant and adjuvant treatment of localized disease as well as in the treatment of metastatic disease. Combining radiotherapy with immunotherapy to potentiate immunotherapy has been used in a variety of cancers other than sarcoma, and there is opportunity to further investigate combining immunotherapy with radiotherapy to try to improve outcomes in sarcoma. In this review, we describe the diversity of the tumor immune microenvironments for sarcomas and describe the immunomodulatory effects of radiotherapy. We discuss studies on the timing of radiotherapy relative to immunotherapy and studies on the radiotherapy dose and fractionation regimen to be used in combination with immunotherapy. We describe the impact of radiotherapy on the tumor immune microenvironment. We review completed and ongoing clinical trials combining radiotherapy with immunotherapy for sarcoma and propose future directions for studies combining immunotherapy with radiotherapy in the treatment of sarcoma.

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肉瘤的免疫疗法和放疗联合疗法

肉瘤是骨与软组织肿瘤中的一种异质性肿瘤。晚期（无法切除或转移）疾病的生存率仍然很低，因此需要改进治疗方法。放疗在局部疾病的新辅助和辅助治疗以及转移性疾病的治疗中发挥着不可或缺的作用。将放疗与免疫疗法相结合以增强免疫疗法的效果，已在肉瘤以外的多种癌症中使用，因此有机会进一步研究将免疫疗法与放疗相结合以改善肉瘤的治疗效果。在这篇综述中，我们描述了肉瘤肿瘤免疫微环境的多样性，并介绍了放疗的免疫调节作用。我们讨论了放疗与免疫治疗时机的相关研究，以及与免疫治疗联合使用的放疗剂量和分次方案的相关研究。我们描述了放疗对肿瘤免疫微环境的影响。我们回顾了已完成和正在进行的结合放疗和免疫疗法治疗肉瘤的临床试验，并提出了结合免疫疗法和放疗治疗肉瘤的未来研究方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in Radiation Oncology 医学-核医学

CiteScore

5.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Each issue of Seminars in Radiation Oncology is compiled by a guest editor to address a specific topic in the specialty, presenting definitive information on areas of rapid change and development. A significant number of articles report new scientific information. Topics covered include tumor biology, diagnosis, medical and surgical management of the patient, and new technologies.