Gastrointestinal Issues in Depression, Anxiety, and Neurodegenerative Diseases: A Systematic Review on Pathways and Clinical Targets Implications.

Ian Richard Lucena Andriolo, Bruna Longo, Dayse Machado de Melo, Márcia Maria de Souza, Rui Daniel Prediger, Luisa Mota da Silva
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Abstract

Introduction: Multiple illnesses commonly involve both the Central Nervous System (CNS) and the Gastrointestinal Tract (GI) simultaneously. Consistent evidence suggests that neurological disorders impair GI tract function and worsen the symptomatology and pathophysiology of digestive disorders. On the other hand, it has been proposed that early functional changes in the GI tract contribute to the genesis of several CNS illnesses. Additionally, the role played by the gut in these diseases can be seen as a paradigm for how the gut and the brain interact.

Methods: We mentioned significant GI symptoms and discussed how the GI tract affects central nervous system illnesses, including depression, anxiety, Alzheimer's disease, and Parkinson's disease in this study. We also explored potential pathophysiological underpinnings and novel targets for the creation of future therapies targeted at gut-brain connections.

Results & discussion: In this situation, modulating the gut microbiota through the administration of fecal microbiota transplants or probiotics may represent a new therapeutic option for this population, not only to treat GI problems but also behavioral problems, given the role that dysbiosis and leaky gut play in many neurological disorders.

Conclusion: Accurate diagnosis and treatment of co-existing illnesses also require coordination between psychiatrists, neurologists, gastroenterologists, and other specialties, as well as a thorough history and thorough physical examination.

抑郁症、焦虑症和神经退行性疾病中的胃肠道问题:关于途径和临床目标影响的系统性综述》。
简介:多种疾病通常同时涉及中枢神经系统(CNS)和胃肠道(GI):多种疾病通常同时涉及中枢神经系统(CNS)和胃肠道(GI)。一致的证据表明,神经系统疾病会损害消化道功能,加重消化系统疾病的症状和病理生理。另一方面,也有人提出,消化道的早期功能变化是多种中枢神经系统疾病的诱因。此外,肠道在这些疾病中所扮演的角色可被视为肠道与大脑相互作用的范例:本研究中,我们提到了重要的消化道症状,并讨论了消化道如何影响中枢神经系统疾病,包括抑郁症、焦虑症、阿尔茨海默病和帕金森病。我们还探讨了潜在的病理生理学基础和新的靶点,以便未来针对肠道与大脑的联系创造疗法:在这种情况下,通过粪便微生物群移植或益生菌来调节肠道微生物群可能是这一人群的一种新的治疗选择,不仅可以治疗消化道问题,还可以治疗行为问题,因为菌群失调和肠道渗漏在许多神经系统疾病中都扮演着重要角色:结论:对并存疾病的准确诊断和治疗还需要精神科医生、神经科医生、肠胃病学家和其他专科医生之间的协调,以及详尽的病史和全面的体格检查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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