A direct spinal cord-computer interface enables the control of the paralysed hand in spinal cord injury.

IF 10.6 1区 医学 Q1 CLINICAL NEUROLOGY
Brain Pub Date : 2024-10-03 DOI:10.1093/brain/awae088
Daniela Souza Oliveira, Matthias Ponfick, Dominik I Braun, Marius Osswald, Marek Sierotowicz, Satyaki Chatterjee, Douglas Weber, Bjoern Eskofier, Claudio Castellini, Dario Farina, Thomas Mehari Kinfe, Alessandro Del Vecchio
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引用次数: 0

Abstract

Paralysis of the muscles controlling the hand dramatically limits the quality of life for individuals living with spinal cord injury (SCI). Here, with a non-invasive neural interface, we demonstrate that eight motor complete SCI individuals (C5-C6) are still able to task-modulate in real-time the activity of populations of spinal motor neurons with residual neural pathways. In all SCI participants tested, we identified groups of motor units under voluntary control that encoded various hand movements. The motor unit discharges were mapped into more than 10 degrees of freedom, ranging from grasping to individual hand-digit flexion and extension. We then mapped the neural dynamics into a real-time controlled virtual hand. The SCI participants were able to match the cue hand posture by proportionally controlling four degrees of freedom (opening and closing the hand and index flexion/extension). These results demonstrate that wearable muscle sensors provide access to spared motor neurons that are fully under voluntary control in complete cervical SCI individuals. This non-invasive neural interface allows the investigation of motor neuron changes after the injury and has the potential to promote movement restoration when integrated with assistive devices.

脊髓-计算机直接接口使脊髓损伤患者能够控制瘫痪的手。
控制手部的肌肉瘫痪极大地限制了脊髓损伤(SCI)患者的生活质量。在这里,我们利用非侵入式神经接口证明,8 名运动完全受损的 SCI 患者(C5-C6)仍能通过残余神经通路实时调节脊髓运动神经元群的活动。在所有接受测试的 SCI 参与者中,我们确定了受自主控制、编码各种手部动作的运动单元群。运动单元的放电被映射到 10 多个自由度中,从抓握到单个手部数字的屈伸。然后,我们将神经动态映射到实时控制的虚拟手部。SCI 参与者能够通过按比例控制四个自由度(手的开合和食指屈伸)来匹配提示手的姿势。这些结果表明,可穿戴式肌肉传感器能够访问完全受颈椎 SCI 患者自主控制的运动神经元。这种非侵入性神经接口可用于调查运动神经元在受伤后的变化,并有可能在与辅助设备结合后促进运动恢复。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Brain
Brain 医学-临床神经学
CiteScore
20.30
自引率
4.10%
发文量
458
审稿时长
3-6 weeks
期刊介绍: Brain, a journal focused on clinical neurology and translational neuroscience, has been publishing landmark papers since 1878. The journal aims to expand its scope by including studies that shed light on disease mechanisms and conducting innovative clinical trials for brain disorders. With a wide range of topics covered, the Editorial Board represents the international readership and diverse coverage of the journal. Accepted articles are promptly posted online, typically within a few weeks of acceptance. As of 2022, Brain holds an impressive impact factor of 14.5, according to the Journal Citation Reports.
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