Carbon nanotubes-reinforced polylactic acid/hydroxyapatite porous scaffolds for bone tissue engineering

IF 2.5 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Frontiers of Materials Science Pub Date : 2024-03-18 DOI:10.1007/s11706-024-0675-y

Weiwei Lan, Mingbo Wang, Zhenjun Lv, Jun Li, Fuying Chen, Ziwei Liang, Di Huang, Xiaochun Wei, Weiyi Chen

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Abstract

In the field of bone defect repair, critical requirements for favorable cytocompatibility and optimal mechanical properties have propelled research efforts towards the development of composite materials. In this study, carbon nanotubes/polylactic acid/hydroxyapatite (CNTs/PLA/HA) scaffolds with different contents (0.5, 1, 1.5 and 2 wt.%) of CNTs were prepared by the thermally induced phase separation (TIPS) method. The results revealed that the composite scaffolds had uniform pores with high porosities over 68% and high through performances. The addition of CNTs significantly enhanced the mechanical properties of resulted PLA/HA, in which the 1.5 wt.% CNTs/PLA/HA composite scaffold demonstrated the optimum mechanical behaviors with the bending elastic modulus of (868.5 ± 12.34) MPa, the tensile elastic modulus of (209.51 ± 12.73) MPa, and the tensile strength of (3.26 ± 0.61) MPa. Furthermore, L929 cells on the 1.5 wt.% CNTs/PLA/HA scaffold displayed good spreading performance and favorable cytocompatibility. Therefore, it is expected that the 1.5 wt.% CNTs/PLA/HA scaffold has potential applications in bone tissue engineering.

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用于骨组织工程的碳纳米管增强聚乳酸/羟基磷灰石多孔支架

摘要在骨缺损修复领域，对良好细胞相容性和最佳机械性能的关键要求推动了复合材料的研究工作。本研究采用热诱导相分离（TIPS）法制备了不同CNT含量（0.5、1、1.5和2 wt.%）的碳纳米管/聚乳酸/羟基磷灰石（CNTs/PLA/HA）支架。结果表明，复合支架具有均匀的孔隙，孔隙率超过 68%，通过性能高。CNTs 的加入显著提高了聚乳酸/羟乙基纤维的力学性能，其中 1.5 wt.% CNTs/PLA/HA 复合支架的力学性能最佳，弯曲弹性模量为（868.5 ± 12.34）兆帕，拉伸弹性模量为（209.51 ± 12.73）兆帕，拉伸强度为（3.26 ± 0.61）兆帕。此外，1.5 wt.% CNTs/PLA/HA 支架上的 L929 细胞显示出良好的铺展性能和细胞相容性。因此，1.5 wt.% CNTs/PLA/HA 支架有望在骨组织工程中得到应用。

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来源期刊

Frontiers of Materials Science MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

4.20

自引率

3.70%

发文量

515

期刊介绍： Frontiers of Materials Science is a peer-reviewed international journal that publishes high quality reviews/mini-reviews, full-length research papers, and short Communications recording the latest pioneering studies on all aspects of materials science. It aims at providing a forum to promote communication and exchange between scientists in the worldwide materials science community. The subjects are seen from international and interdisciplinary perspectives covering areas including (but not limited to): Biomaterials including biomimetics and biomineralization; Nano materials; Polymers and composites; New metallic materials; Advanced ceramics; Materials modeling and computation; Frontier materials synthesis and characterization; Novel methods for materials manufacturing; Materials performance; Materials applications in energy, information and biotechnology.