The roles of HCV core protein and its binding host factor in virus assembly and release

IF 2 Q4 VIROLOGY
Kyo Izumida, Eiji Morita
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Abstract

Hepatitis C virus (HCV) is a well-known virus that causes liver diseases such as liver cirrhosis and hepatocellular carcinoma. For several decades, numerous studies have been conducted to unravel the life cycle and molecular mechanisms of this virus with the aim of developing strategies to combat diseases caused by its infection. In this review, we summarize HCV assembly to budding, focusing on one of the structural proteins, the core, a viral capsid that binds both the viral genome and host membrane, along with the core-interacting host partners. The HCV core matures in the endoplasmic reticulum (ER), localizes at the lipid droplet (LD), and shuttles between the LD and ER to form viral particles. This process is controlled by many host factors known to binds core proteins, such as diacylglycerol acyltransferase-1 (DGAT-1), Rab18, μ subunit of the clathrin adaptor protein complex 2 (AP2M1), nuclear pore complex protein 98 (Nup98), Cortactin, group IVA phospholipase A2 (PLA2G4A) etc. Virion budding is thought to involve contributions from endosomal sorting complexes required for transport (ESCRT), similar to other envelope viruses. We delved into potential perspectives to enhance our understanding of the HCV mechanism by drawing insights from existing studies.

HCV 核心蛋白及其结合宿主因子在病毒组装和释放中的作用
丙型肝炎病毒(HCV)是一种众所周知的导致肝硬化和肝细胞癌等肝脏疾病的病毒。数十年来,人们进行了大量研究,以揭示这种病毒的生命周期和分子机制,从而开发出对抗由其感染引起的疾病的策略。在这篇综述中,我们总结了 HCV 从组装到出芽的整个过程,重点研究了其中一种结构蛋白--核心蛋白,即同时结合病毒基因组和宿主膜的病毒帽,以及与核心蛋白相互作用的宿主伙伴。HCV 核心在内质网(ER)中成熟,定位于脂滴(LD),并在 LD 和 ER 之间穿梭,形成病毒颗粒。这一过程受许多已知能与核心蛋白结合的宿主因子控制,如二酰甘油酰基转移酶-1(DGAT-1)、Rab18、clathrin 适应蛋白复合物 2(AP2M1)的μ亚基、核孔复合物蛋白 98(Nup98)、Cortactin、IVA 组磷脂酶 A2(PLA2G4A)等。与其他包膜病毒类似,病毒出芽被认为涉及运输所需的内体分拣复合物(ESCRT)的贡献。我们从现有研究中汲取灵感,深入探讨了增强我们对 HCV 机制理解的潜在视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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