{"title":"Unstable cores are the source of instability in chemical reaction networks","authors":"Nicola Vassena, Peter F. Stadler","doi":"10.1098/rspa.2023.0694","DOIUrl":null,"url":null,"abstract":"<p>In biochemical networks, complex dynamical features such as superlinear growth and oscillations are classically considered a consequence of autocatalysis. For the large class of parameter-rich kinetic models, which includes generalized mass action kinetics and Michaelis–Menten kinetics, we show that certain submatrices of the stoichiometric matrix, so-called unstable cores, are sufficient for a reaction network to admit instability and potentially give rise to such complex dynamical behaviour. The determinant of the submatrix distinguishes unstable-positive feedbacks, with a single real-positive eigenvalue, and unstable-negative feedbacks without real-positive eigenvalues. Autocatalytic cores turn out to be exactly the unstable-positive feedbacks that are Metzler matrices. Thus there are sources of dynamical instability in chemical networks that are unrelated to autocatalysis. We use such intuition to design non-autocatalytic biochemical networks with superlinear growth and oscillations.</p>","PeriodicalId":20716,"journal":{"name":"Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences","volume":null,"pages":null},"PeriodicalIF":2.9000,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1098/rspa.2023.0694","RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
In biochemical networks, complex dynamical features such as superlinear growth and oscillations are classically considered a consequence of autocatalysis. For the large class of parameter-rich kinetic models, which includes generalized mass action kinetics and Michaelis–Menten kinetics, we show that certain submatrices of the stoichiometric matrix, so-called unstable cores, are sufficient for a reaction network to admit instability and potentially give rise to such complex dynamical behaviour. The determinant of the submatrix distinguishes unstable-positive feedbacks, with a single real-positive eigenvalue, and unstable-negative feedbacks without real-positive eigenvalues. Autocatalytic cores turn out to be exactly the unstable-positive feedbacks that are Metzler matrices. Thus there are sources of dynamical instability in chemical networks that are unrelated to autocatalysis. We use such intuition to design non-autocatalytic biochemical networks with superlinear growth and oscillations.
期刊介绍:
Proceedings A has an illustrious history of publishing pioneering and influential research articles across the entire range of the physical and mathematical sciences. These have included Maxwell"s electromagnetic theory, the Braggs" first account of X-ray crystallography, Dirac"s relativistic theory of the electron, and Watson and Crick"s detailed description of the structure of DNA.