{"title":"Evaluating the effect of liposomes containing vitamin E on bone metabolism","authors":"Babak Akbari, Narges Shomalizadeh, Shabnam Shahi","doi":"10.1557/s43578-024-01320-w","DOIUrl":null,"url":null,"abstract":"<p>To prevent causing pain during movement of the skeleton system, modern drug delivery systems use carriers to protect the drug, deliver it to the target site, and increase its efficiency. Liposomal encapsulation technology is one of the most promising carriers due to its biocompatibility, natural components, and cell membrane-like structure. In this study, liposomes containing vitamin E were used to increase osteoblast cells’ metabolism. Liposomes were prepared by hydrating a lipid film and loaded using a passive loading technique. DLS and zeta potential tests showed good stability and optimal size distribution. The cell culture results showed non-toxicity and improved bone cell growth. Alkaline phosphatase activity increased in the samples containing vitamin E. Samples were prepared in three DOPE: CHEMS ratios and sonication times. The best result was from the sample with a 4:1 ratio and 20-min sonication time, which showed the maximum vitamin E loading capacity.</p><h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>\n","PeriodicalId":16306,"journal":{"name":"Journal of Materials Research","volume":"15 1","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Materials Research","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1557/s43578-024-01320-w","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
To prevent causing pain during movement of the skeleton system, modern drug delivery systems use carriers to protect the drug, deliver it to the target site, and increase its efficiency. Liposomal encapsulation technology is one of the most promising carriers due to its biocompatibility, natural components, and cell membrane-like structure. In this study, liposomes containing vitamin E were used to increase osteoblast cells’ metabolism. Liposomes were prepared by hydrating a lipid film and loaded using a passive loading technique. DLS and zeta potential tests showed good stability and optimal size distribution. The cell culture results showed non-toxicity and improved bone cell growth. Alkaline phosphatase activity increased in the samples containing vitamin E. Samples were prepared in three DOPE: CHEMS ratios and sonication times. The best result was from the sample with a 4:1 ratio and 20-min sonication time, which showed the maximum vitamin E loading capacity.
为了防止在骨骼系统运动时引起疼痛，现代给药系统使用载体来保护药物，将药物输送到目标部位，并提高其效率。脂质体封装技术因其生物相容性、天然成分和类细胞膜结构而成为最有前途的载体之一。本研究利用含有维生素 E 的脂质体来提高成骨细胞的新陈代谢。脂质体是通过水合脂膜制备的，并采用被动装载技术进行装载。DLS 和 zeta 电位测试表明其具有良好的稳定性和最佳尺寸分布。细胞培养结果表明，脂质体无毒，并能改善骨细胞的生长。碱性磷酸酶活性在含有维生素 E 的样品中有所增加：CHEMS 比率和超声时间制备样品。结果表明，比例为 4:1 和超声时间为 20 分钟的样品的维生素 E 负载能力最强。
期刊介绍：
Journal of Materials Research (JMR) publishes the latest advances about the creation of new materials and materials with novel functionalities, fundamental understanding of processes that control the response of materials, and development of materials with significant performance improvements relative to state of the art materials. JMR welcomes papers that highlight novel processing techniques, the application and development of new analytical tools, and interpretation of fundamental materials science to achieve enhanced materials properties and uses. Materials research papers in the following topical areas are welcome.
• Novel materials discovery
• Electronic, photonic and magnetic materials
• Energy Conversion and storage materials
• New thermal and structural materials
• Soft materials
• Biomaterials and related topics
• Nanoscale science and technology
• Advances in materials characterization methods and techniques
• Computational materials science, modeling and theory
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