Cross Talk Between Cells and the Current Bioceramics in Bone Regeneration: A Comprehensive Review.

IF 3.2 4区 医学 Q3 CELL & TISSUE ENGINEERING
Danial Khayatan, Asal Bagherzadeh Oskouei, Mostafa Alam, Meysam Mohammadikhah, Ashkan Badkoobeh, Mohsen Golkar, Kamyar Abbasi, Shahryar Karami, Reza Sayyad Soufdoost, Lotfollah Kamali Hakim, Ahmed Hussain, Hamid Tebyaniyan, Artak Heboyan
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Abstract

The conventional approach for addressing bone defects and stubborn non-unions typically involves the use of autogenous bone grafts. Nevertheless, obtaining these grafts can be challenging, and the procedure can lead to significant morbidity. Three primary treatment strategies for managing bone defects and non-unions prove resistant to conventional treatments: synthetic bone graft substitutes (BGS), a combination of BGS with bioactive molecules, and the use of BGS in conjunction with stem cells. In the realm of synthetic BGS, a multitude of biomaterials have emerged for creating scaffolds in bone tissue engineering (TE). These materials encompass biometals like titanium, iron, magnesium, and zinc, as well as bioceramics such as hydroxyapatite (HA) and tricalcium phosphate (TCP). Bone TE scaffolds serve as temporary implants, fostering tissue ingrowth and the regeneration of new bone. They are meticulously designed to enhance bone healing by optimizing geometric, mechanical, and biological properties. These scaffolds undergo continual remodeling facilitated by bone cells like osteoblasts and osteoclasts. Through various signaling pathways, stem cells and bone cells work together to regulate bone regeneration when a portion of bone is damaged or deformed. By targeting signaling pathways, bone TE can improve bone defects through effective therapies. This review provided insights into the interplay between cells and the current state of bioceramics in the context of bone regeneration.

骨再生中细胞与当前生物陶瓷之间的交叉对话:全面回顾。
处理骨缺损和顽固性非骨连接的传统方法通常包括使用自体骨移植。然而,获得这些移植物可能具有挑战性,而且该过程可能导致严重的发病率。治疗骨缺损和非椎体连接的三种主要治疗策略被证明对传统治疗方法具有抵抗力:合成骨移植替代物(BGS)、BGS 与生物活性分子的结合,以及 BGS 与干细胞的结合使用。在合成骨移植替代物领域,出现了多种生物材料,用于在骨组织工程(TE)中制作支架。这些材料包括钛、铁、镁和锌等生物金属,以及羟基磷灰石(HA)和磷酸三钙(TCP)等生物陶瓷。骨 TE 支架可作为临时植入物,促进组织生长和新骨再生。它们经过精心设计,通过优化几何、机械和生物特性来促进骨愈合。这些支架在骨细胞(如成骨细胞和破骨细胞)的促进下不断重塑。当部分骨骼受损或变形时,干细胞和骨细胞通过各种信号通路共同调节骨骼再生。通过靶向信号通路,骨TE可以通过有效的疗法改善骨缺损。这篇综述深入探讨了细胞之间的相互作用以及生物陶瓷在骨再生方面的现状。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cell Transplantation
Cell Transplantation 生物-细胞与组织工程
CiteScore
6.00
自引率
3.00%
发文量
97
审稿时长
6 months
期刊介绍: Cell Transplantation, The Regenerative Medicine Journal is an open access, peer reviewed journal that is published 12 times annually. Cell Transplantation is a multi-disciplinary forum for publication of articles on cell transplantation and its applications to human diseases. Articles focus on a myriad of topics including the physiological, medical, pre-clinical, tissue engineering, stem cell, and device-oriented aspects of the nervous, endocrine, cardiovascular, and endothelial systems, as well as genetically engineered cells. Cell Transplantation also reports on relevant technological advances, clinical studies, and regulatory considerations related to the implantation of cells into the body in order to provide complete coverage of the field.
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