The association of 25(OH)D, interleukin-4, interleukin-5, and interleukin-13 levels with the burden of soil-transmitted helminth infection in stunted children aged 24-59 months.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-12-01 Epub Date: 2024-03-18 DOI:10.1080/08916934.2024.2330394

Riyadi Adrizain, Monika Verena Nagari, Djatnika Setiabudi, Afiat Berbudi, Budi Setiabudiawan

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引用次数: 0

Abstract

Soil-transmitted helminth (STH) among children aged 24-59 months is one cause of chronic infection that could lead to stunting. The association of 25(OH)D and immune responses during chronic infection in stunted populations has not yet been well established. An association study of case-control data was conducted in Bandung district from October 2019 to January 2023. Sociodemographic factors, stool samples, and serum levels of 25(OH)D, interleukin-4 (IL-4), interleukin-5 (IL-5), and interleukin-13 (IL-13) were assessed. Statistical analysis was performed to evaluate the prevalence and association of 25(OH)D, IL-4, IL-5, and IL-13 with the burden of STH infection in stunted children. In total, 401 stunted children were recruited. A higher burden of STH infection was found for lower levels of IL-5 (r = -0.477; p = 0.004) and IL-13 (r = -0.433; p = 0.028). Thus, 25(OH)D, IL-4, IL-5, and IL-13 play a role in the burden of STH infection.

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25(OH)D 、白细胞介素-4、白细胞介素-5 和白细胞介素-13 水平与 24-59 个月发育不良儿童土壤传播蠕虫感染负担的关系。

在 24-59 个月大的儿童中，土壤传播的蠕虫（STH）是导致发育迟缓的慢性感染的原因之一。25（OH）D与发育迟缓人群慢性感染期间免疫反应的关系尚未得到很好的证实。2019年10月至2023年1月期间，万隆地区开展了一项病例对照数据关联研究。研究人员评估了社会人口学因素、粪便样本以及血清中25（OH）D、白细胞介素-4（IL-4）、白细胞介素-5（IL-5）和白细胞介素-13（IL-13）的水平。通过统计分析，评估了 25（OH）D、IL-4、IL-5 和 IL-13 在发育迟缓儿童中的流行率以及与 STH 感染负担的关联。共招募了 401 名发育迟缓儿童。结果发现，IL-5（r = -0.477；p = 0.004）和 IL-13（r = -0.433；p = 0.028）水平越低，感染 STH 的负担越高。因此，25(OH)D、IL-4、IL-5 和 IL-13 在 STH 感染负担中发挥着作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567