Molecular, Structural, and Functional Diversity of Universal Stress Proteins (USPs) in Bacteria, Plants, and Their Biotechnological Applications

IF 1.9 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Bilkees Nabi, Manoj Kumawat, Neeraj Ahlawat, Sushma Ahlawat
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引用次数: 0

Abstract

Universal stress proteins (USPs) are widely distributed and play crucial roles in cellular responses to biotic and abiotic stresses. These roles include regulating cell growth and development, cell motility, hypoxia responses, and ion sequestration. With the increasing frequency and intensity of extreme weather events due to climate change, pathogens have developed different strategies to withstand environmental stresses, in which USPs play a significant role in their survival and virulence. In this study, we analyzed the importance of USPs in various organisms, such as archaea, plants, and fungi, as a parameter that influences their survival. We discussed the different types Of USPs and their role, aiming to carry out fundamental research in this field to identify significant constraints for better understanding of USP functions at molecular level. Additionally, we discussed concepts and research techniques that could help overcome these hurdles and facilitate new molecular approaches to better understand and target USPs as important stress adaptation and survival regulators. Although the precise characteristics of USPs are still unclear, numerous innovative uses have already been developed, tested, and implemented. Complementary approaches to basic research and applications, as well as new technology and analytical techniques, may offer insights into the cryptic but crucial activities of USPs in various living systems.

Graphical Abstract

Shows the different environmental stresses faced by plants and microbes and how they respond by generating stress proteins, which are enhanced when stressors trigger organisms and help the organism in stress tolerance and resistance and the pathogenesis of microbes.

细菌、植物中通用应激蛋白 (USP) 的分子、结构和功能多样性及其生物技术应用。
通用应激蛋白(USP)分布广泛,在细胞应对生物和非生物应激方面发挥着至关重要的作用。这些作用包括调节细胞生长和发育、细胞运动、缺氧反应和离子螯合。随着气候变化导致极端天气事件发生的频率和强度不断增加,病原体开发出了不同的策略来抵御环境压力,其中 USP 在病原体的生存和毒力方面发挥了重要作用。在本研究中,我们分析了 USPs 作为影响生物生存的一个参数在古细菌、植物和真菌等各种生物体中的重要性。我们讨论了 USP 的不同类型及其作用,旨在开展该领域的基础研究,找出重要的制约因素,以便更好地了解 USP 在分子水平上的功能。此外,我们还讨论了有助于克服这些障碍和促进新分子方法的概念和研究技术,以便更好地理解和瞄准作为重要应激适应和生存调节因子的 USP。尽管 USP 的确切特征尚不清楚,但已经开发、测试和实施了许多创新用途。基础研究和应用的互补方法以及新技术和分析技术可能会让人们深入了解 USP 在各种生命系统中隐秘而重要的活动。
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来源期刊
The Protein Journal
The Protein Journal 生物-生化与分子生物学
CiteScore
5.20
自引率
0.00%
发文量
57
审稿时长
12 months
期刊介绍: The Protein Journal (formerly the Journal of Protein Chemistry) publishes original research work on all aspects of proteins and peptides. These include studies concerned with covalent or three-dimensional structure determination (X-ray, NMR, cryoEM, EPR/ESR, optical methods, etc.), computational aspects of protein structure and function, protein folding and misfolding, assembly, genetics, evolution, proteomics, molecular biology, protein engineering, protein nanotechnology, protein purification and analysis and peptide synthesis, as well as the elucidation and interpretation of the molecular bases of biological activities of proteins and peptides. We accept original research papers, reviews, mini-reviews, hypotheses, opinion papers, and letters to the editor.
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