Sinonasal Tumors Masquerading as Invasive Fungal Sinusitis (IFS).

IF 1.3 4区医学 Q3 OTORHINOLARYNGOLOGY

Annals of Otology Rhinology and Laryngology Pub Date : 2024-06-01 Epub Date: 2024-03-16 DOI:10.1177/00034894241238864

Kaitlynne Y Pak, Victor B Hsue, Matthew K Lee, Michelle M Chen, Bonnie Balzer, Arthur W Wu, Dennis M Tang

{"title":"Sinonasal Tumors Masquerading as Invasive Fungal Sinusitis (IFS).","authors":"Kaitlynne Y Pak, Victor B Hsue, Matthew K Lee, Michelle M Chen, Bonnie Balzer, Arthur W Wu, Dennis M Tang","doi":"10.1177/00034894241238864","DOIUrl":null,"url":null,"abstract":"Objectives: Fungal tissue invasion in the setting of sinonasal malignancy has been rarely described in the literature. Only a handful of studies have discussed cases of suspected chronic and acute IFS (CIFS and AIFS, respectively), having an underlying undifferentiated sinonasal carcinoma, sinonasal teratocarcinosarcoma, and NK/T-cell lymphoma.Methods: Here, we describe 3 cases of carcinoma mimicking IFS from a single institution.Results: Each of our patients presented with sinonasal complaints as an outpatient in the setting of immunosuppression. Intranasal biopsies consistently were predominated by necrotic debris, with and without fungal elements, ultimately leading to a delay of oncologic care. The final pathologies included NK/T-cell lymphoma and SNEC. All patients were followed by radiation and chemotherapy, with 1 case of mortality.Conclusions: We aim to emphasize the importance of obtaining viable tissue as pathology specimens as the presence of necrosis with fungal elements may limit the diagnosis and ultimately delay the care of an underlying sinonasal carcinoma.","PeriodicalId":50975,"journal":{"name":"Annals of Otology Rhinology and Laryngology","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Otology Rhinology and Laryngology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/00034894241238864","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/3/16 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: Fungal tissue invasion in the setting of sinonasal malignancy has been rarely described in the literature. Only a handful of studies have discussed cases of suspected chronic and acute IFS (CIFS and AIFS, respectively), having an underlying undifferentiated sinonasal carcinoma, sinonasal teratocarcinosarcoma, and NK/T-cell lymphoma.

Methods: Here, we describe 3 cases of carcinoma mimicking IFS from a single institution.

Results: Each of our patients presented with sinonasal complaints as an outpatient in the setting of immunosuppression. Intranasal biopsies consistently were predominated by necrotic debris, with and without fungal elements, ultimately leading to a delay of oncologic care. The final pathologies included NK/T-cell lymphoma and SNEC. All patients were followed by radiation and chemotherapy, with 1 case of mortality.

Conclusions: We aim to emphasize the importance of obtaining viable tissue as pathology specimens as the presence of necrosis with fungal elements may limit the diagnosis and ultimately delay the care of an underlying sinonasal carcinoma.

查看原文本刊更多论文

伪装成侵袭性真菌性鼻窦炎 (IFS) 的鼻窦肿瘤。

目的：文献中很少描述鼻窦恶性肿瘤情况下的真菌组织侵犯。只有少数研究讨论了疑似慢性和急性 IFS（分别为 CIFS 和 AIFS）的病例，这些病例均伴有潜在的鼻窦未分化癌、鼻窦畸胎肉瘤和 NK/T 细胞淋巴瘤：结果：我们的每位患者都是在免疫抑制的情况下出现鼻窦不适的门诊病人。鼻内活检结果始终以坏死碎屑为主，伴有或不伴有真菌成分，最终导致肿瘤治疗延误。最终的病理结果包括 NK/T 细胞淋巴瘤和 SNEC。所有患者均接受了放疗和化疗，其中1例死亡：我们旨在强调获取存活组织作为病理标本的重要性，因为带有真菌成分的坏死可能会限制诊断，最终延误对潜在鼻窦癌的治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Annals of Otology Rhinology and Laryngology 医学-耳鼻喉科学

CiteScore

3.10

自引率

7.10%

发文量

171

审稿时长

4-8 weeks

期刊介绍： The Annals of Otology, Rhinology & Laryngology publishes original manuscripts of clinical and research importance in otolaryngology–head and neck medicine and surgery, otology, neurotology, bronchoesophagology, laryngology, rhinology, head and neck oncology and surgery, plastic and reconstructive surgery, pediatric otolaryngology, audiology, and speech pathology. In-depth studies (supplements), papers of historical interest, and reviews of computer software and applications in otolaryngology are also published, as well as imaging, pathology, and clinicopathology studies, book reviews, and letters to the editor. AOR is the official journal of the American Broncho-Esophagological Association.