{"title":"Numerical study of the induction of intratumoral apoptosis under microwave ablation by changing slot length of microwave coaxial antenna.","authors":"Hyunjung Kim, Donghyuk Kim","doi":"10.1007/s11517-024-03068-1","DOIUrl":null,"url":null,"abstract":"<p><p>Recent advances in technology have led to an increase in the detection of previously undetected deep-located tumor tissue. As a result, the medical field is using a variety of methods to treat deep-located tumors, and minimally invasive treatment techniques are being explored. In this study, therapeutic effect of microwave ablation (MWA) on tumor generated inside liver tissue was analyzed through numerical analysis. The distribution of electromagnetic fields in biological tissues emitted by microwave coaxial antenna (MCA) was calculated through the wave equation, and the thermal behavior of the tissue was analyzed through the Pennes bioheat equation. Among various treatment conditions constituting MWA, tumor radius and the slot length inside the MCA were changed, and the resulting treatment effect was quantitatively confirmed through three apoptotic variables. As a result, each tumor radius has optimal power condition for MWA, 2.6W, 2.4W, and 3.0W respectively. This study confirmed optimal therapeutic conditions for MWA. Three apoptotic variables were used to quantitatively identify apoptotic temperature maintenance inside tumor tissue and thermal damage to surrounding normal tissue. The findings of this study are expected to serve as a standard for treatment based on actual MWA treatment.</p>","PeriodicalId":49840,"journal":{"name":"Medical & Biological Engineering & Computing","volume":null,"pages":null},"PeriodicalIF":2.6000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical & Biological Engineering & Computing","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1007/s11517-024-03068-1","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/3/15 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS","Score":null,"Total":0}
引用次数: 0
Abstract
Recent advances in technology have led to an increase in the detection of previously undetected deep-located tumor tissue. As a result, the medical field is using a variety of methods to treat deep-located tumors, and minimally invasive treatment techniques are being explored. In this study, therapeutic effect of microwave ablation (MWA) on tumor generated inside liver tissue was analyzed through numerical analysis. The distribution of electromagnetic fields in biological tissues emitted by microwave coaxial antenna (MCA) was calculated through the wave equation, and the thermal behavior of the tissue was analyzed through the Pennes bioheat equation. Among various treatment conditions constituting MWA, tumor radius and the slot length inside the MCA were changed, and the resulting treatment effect was quantitatively confirmed through three apoptotic variables. As a result, each tumor radius has optimal power condition for MWA, 2.6W, 2.4W, and 3.0W respectively. This study confirmed optimal therapeutic conditions for MWA. Three apoptotic variables were used to quantitatively identify apoptotic temperature maintenance inside tumor tissue and thermal damage to surrounding normal tissue. The findings of this study are expected to serve as a standard for treatment based on actual MWA treatment.
近来技术的进步使以前未被发现的深部肿瘤组织的检测率有所提高。因此,医学界正在使用多种方法治疗深部肿瘤,并正在探索微创治疗技术。本研究通过数值分析,分析了微波消融(MWA)对肝组织内产生的肿瘤的治疗效果。通过波方程计算了微波同轴天线(MCA)发射的电磁场在生物组织中的分布,并通过彭尼斯生物热方程分析了组织的热行为。在构成微波同轴电缆的各种治疗条件中,改变肿瘤半径和微波同轴电缆内的槽长,通过三个凋亡变量来定量确认治疗效果。结果发现,每种肿瘤半径的 MWA 最佳功率条件分别为 2.6W、2.4W 和 3.0W。这项研究证实了 MWA 的最佳治疗条件。研究使用了三个凋亡变量来定量确定肿瘤组织内的凋亡温度维持情况和对周围正常组织的热损伤情况。本研究的结果有望作为基于实际 MWA 治疗的治疗标准。
期刊介绍:
Founded in 1963, Medical & Biological Engineering & Computing (MBEC) continues to serve the biomedical engineering community, covering the entire spectrum of biomedical and clinical engineering. The journal presents exciting and vital experimental and theoretical developments in biomedical science and technology, and reports on advances in computer-based methodologies in these multidisciplinary subjects. The journal also incorporates new and evolving technologies including cellular engineering and molecular imaging.
MBEC publishes original research articles as well as reviews and technical notes. Its Rapid Communications category focuses on material of immediate value to the readership, while the Controversies section provides a forum to exchange views on selected issues, stimulating a vigorous and informed debate in this exciting and high profile field.
MBEC is an official journal of the International Federation of Medical and Biological Engineering (IFMBE).