Characterizing Heart Rate Variability Response to Maximal Exercise Testing in People with Huntington's Disease.

IF 2.1 Q3 NEUROSCIENCES
Haoyu Li, Radhika Desai, Norberto Quiles, Lori Quinn, Ciarán Friel
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Abstract

Background: Huntington's disease (HD) is an autosomal dominant, neurodegenerative disease that involves dysfunction in the autonomic nervous system (ANS). Heart rate variability (HRV) is a valid and noninvasive measure for ANS dysfunction, yet no study has characterized HRV response to exercise in people with HD.

Objective: Characterize HRV response to exercise in individuals with HD and explore its implications for exercise prescription and cardiac dysautonomia mechanisms.

Methods: 19 participants with HD were recruited as part of a cohort of individuals enrolled in the Physical Activity and Exercise Outcomes in Huntington's Disease (PACE-HD) study at Teachers College, Columbia University (TC). 13 non-HD age- and gender-matched control participants were also recruited from TC. HRV was recorded with a Polar H10 heart rate (HR) monitor before, during, and after a ramp cycle-ergometer exercise test.

Results: Participants with HD showed reduced HR peak (p < 0.01) and HR reserve (p < 0.001) compared with controls. Participants with HD demonstrated reduced root mean square of successive differences between normal-to-normal intervals (RMSSD) and successive differences of normal-to-normal intervals (SDSD) at rest (p < 0.001). Participants with HD also showed differences for low frequency (LF) power (p < 0.01), high frequency (HF) normalized units (nu) (p < 0.05), LF (nu) (p < 0.001), and HF/LF ratio (p < 0.05) compared with controls.

Conclusions: We found reduced aerobic exercise capacity and sympathovagal dysautonomia both at rest and during post-exercise recovery in people with HD, suggesting modified exercise prescription may be required for people with HD. Further investigations focusing on cardiac dysautonomia and underlying mechanisms of sympathovagal dysautonomia in people with HD are warranted.

描述亨廷顿氏病患者对最大运动量测试的心率变异反应。
背景:亨廷顿氏病(Huntington's disease,HD)是一种常染色体显性遗传的神经退行性疾病,涉及自律神经系统(ANS)功能障碍。心率变异性(HRV)是测量自律神经系统功能障碍的一种有效且无创的方法,但目前还没有任何研究能描述 HD 患者心率变异性对运动的反应:方法:招募 19 名 HD 患者,作为哥伦比亚大学师范学院(TC)亨廷顿氏病体育活动和运动结果(PACE-HD)研究的参与者队列的一部分。此外,还从哥伦比亚大学师范学院(TC)招募了 13 名年龄和性别匹配的非亨廷顿病患者作为对照组。在斜坡循环-测力计运动测试之前、期间和之后,使用 Polar H10 心率(HR)监测器记录心率变异:结果:HD 患者的心率峰值降低了(p 结论:HD 患者的心率峰值降低了:我们发现,HD 患者在静息状态和运动后恢复期间的有氧运动能力和交感神经自主神经功能障碍均有所下降,这表明可能需要对 HD 患者的运动处方进行调整。有必要进一步研究 HD 患者的心脏自主神经功能障碍和交感神经自主神经功能障碍的潜在机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.80
自引率
9.70%
发文量
60
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