A naked-eye colorimetric assay for highly sensitive detection of CL-20 explosive

IF 2.6 3区医学 Q2 CHEMISTRY, ANALYTICAL

Forensic Chemistry Pub Date : 2024-03-13 DOI:10.1016/j.forc.2024.100568

Jian Tang , Jinxiang Wu , Yi He

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Abstract

2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) stands as the most energetically condensed explosive ever found, and poses a great security threat to humans. Here we report a naked-eye colorimetric assay for highly sensitive detection of CL-20. Through effective cascading of the hydrolysis process of CL-20 with nitrite-involved Griess reaction to yield a pink-colored azo product, the visual quantification of CL-20 is realized by taking advantage of corresponding colorimetric signals. Under optimal experimental conditions, the present colorimetric assay is successfully used for highly selective determination of CL-20 in deionized water and environmental water samples with a nanomolar sensitivity. The resulting limit of detection is much lower than conventional methods. Moreover, benefiting from the distinct color change of the detection solution, direct naked-eye semi-quantitative analysis of CL-20 is achieved with a threshold concentration of 1 μM. Such simple, cost-effective, selective, and highly sensitive visual colorimetric assay will have valuable applications in public safety, environmental monitoring, and other related fields.

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用于高灵敏度检测 CL-20 爆炸物的裸眼比色测定法

2,4,6,8,10,12-六硝基-2,4,6,8,10,12-六氮唑乌齐坦（CL-20）是迄今为止发现的能量最凝聚的爆炸物，对人类构成极大的安全威胁。在此，我们报告了一种高灵敏度检测 CL-20 的裸眼比色法。通过将 CL-20 的水解过程与亚硝酸盐参与的格里斯反应有效串联，生成粉红色的偶氮产物，利用相应的比色信号实现了对 CL-20 的目视定量。在最佳实验条件下，本比色测定法可成功用于去离子水和环境水样中 CL-20 的高选择性测定，灵敏度达到纳摩尔级。其检测限远远低于传统方法。此外，得益于检测溶液明显的颜色变化，CL-20 可直接通过肉眼进行半定量分析，阈值浓度为 1 μM。这种简单、经济、高选择性和高灵敏度的目视比色法将在公共安全、环境监测和其他相关领域得到有价值的应用。

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来源期刊

Forensic Chemistry CHEMISTRY, ANALYTICAL-

CiteScore

5.70

自引率

14.80%

发文量

审稿时长

46 days

期刊介绍： Forensic Chemistry publishes high quality manuscripts focusing on the theory, research and application of any chemical science to forensic analysis. The scope of the journal includes fundamental advancements that result in a better understanding of the evidentiary significance derived from the physical and chemical analysis of materials. The scope of Forensic Chemistry will also include the application and or development of any molecular and atomic spectrochemical technique, electrochemical techniques, sensors, surface characterization techniques, mass spectrometry, nuclear magnetic resonance, chemometrics and statistics, and separation sciences (e.g. chromatography) that provide insight into the forensic analysis of materials. Evidential topics of interest to the journal include, but are not limited to, fingerprint analysis, drug analysis, ignitable liquid residue analysis, explosives detection and analysis, the characterization and comparison of trace evidence (glass, fibers, paints and polymers, tapes, soils and other materials), ink and paper analysis, gunshot residue analysis, synthetic pathways for drugs, toxicology and the analysis and chemistry associated with the components of fingermarks. The journal is particularly interested in receiving manuscripts that report advances in the forensic interpretation of chemical evidence. Technology Readiness Level: When submitting an article to Forensic Chemistry, all authors will be asked to self-assign a Technology Readiness Level (TRL) to their article. The purpose of the TRL system is to help readers understand the level of maturity of an idea or method, to help track the evolution of readiness of a given technique or method, and to help filter published articles by the expected ease of implementation in an operation setting within a crime lab.