Time to childbirth and assisted reproductive treatment in women with congenital heart disease

IF 2.8 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Open Heart Pub Date : 2024-03-01 DOI:10.1136/openhrt-2023-002591

Sara Jonsson, Inger Sundström-Poromaa, Bengt Johansson, Jenny Alenius Dahlqvist, Christina Christersson, Mikael Dellborg, Alexandra Trzebiatowska-Krzynska, Peder Sörensson, Ulf Thilén, Anna-Karin Wikström, Annika Bay

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引用次数: 0

Abstract

Objective To investigate the time to first childbirth and to compare the prevalence of assisted reproductive treatment (ART) in women with congenital heart disease (CHD) compared with women without CHD. Methods All women in the national register for CHD who had a registered first childbirth in the Swedish Pregnancy Register between 2014 and 2019 were identified. These individuals (cases) were matched by birth year and municipality to women without CHD (controls) in a 1:5 ratio. The time from the 18th birthday to the first childbirth and the prevalence of ART was compared between cases and controls. Results 830 first childbirths in cases were identified and compared with 4137 controls. Cases were slightly older at the time for first childbirth (28.9 vs 28.5 years, p=0.04) and ART was more common (6.1% vs 4.0%, p<0.01) compared with controls. There were no differences in ART when stratifying for the complexity of CHD. For all women, higher age was associated with ART treatment (OR 1.24, 95% CI 1.20 to 1.28). Conclusions Women with and without CHD who gave birth to a first child did so at similar ages. ART was more common in women with CHD, but disease severity did not influence the need for ART. Age was an important risk factor for ART also in women with CHD and should be considered in consultations with these patients. Data are available upon reasonable request.

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患有先天性心脏病的妇女的分娩时间和辅助生殖治疗

目的调查患有先天性心脏病（CHD）的妇女与未患有先天性心脏病的妇女的初产时间，并比较两者接受辅助生殖治疗（ART）的比例。方法确定所有在 2014 年至 2019 年期间在瑞典妊娠登记册中登记了首次分娩的 CHD 全国登记妇女。这些人（病例）按出生年份和市镇与无 CHD 妇女（对照组）以 1:5 的比例进行配对。比较了病例和对照组之间从 18 岁生日到首次分娩的时间以及 ART 的流行率。结果确定了 830 例初产妇，并与 4137 例对照组进行了比较。与对照组相比，病例的初产年龄稍大（28.9 岁对 28.5 岁，P=0.04），抗逆转录病毒疗法更常见（6.1% 对 4.0%，P<0.01）。根据心脏病的复杂程度进行分层后，ART 没有差异。在所有女性中，年龄越大，接受抗逆转录病毒疗法的比例越高（OR 1.24，95% CI 1.20 至 1.28）。结论患有和未患有冠心病的妇女生育第一胎的年龄相似。抗逆转录病毒疗法在患有先天性心脏病的妇女中更为常见，但疾病的严重程度并不影响对抗逆转录病毒疗法的需求。年龄也是患有先天性心脏病的女性进行抗逆转录病毒疗法的一个重要风险因素，在咨询这些患者时应加以考虑。如有合理要求，可提供相关数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Heart CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

4.60

自引率

3.70%

发文量

145

审稿时长

20 weeks

期刊介绍： Open Heart is an online-only, open access cardiology journal that aims to be “open” in many ways: open access (free access for all readers), open peer review (unblinded peer review) and open data (data sharing is encouraged). The goal is to ensure maximum transparency and maximum impact on research progress and patient care. The journal is dedicated to publishing high quality, peer reviewed medical research in all disciplines and therapeutic areas of cardiovascular medicine. Research is published across all study phases and designs, from study protocols to phase I trials to meta-analyses, including small or specialist studies. Opinionated discussions on controversial topics are welcomed. Open Heart aims to operate a fast submission and review process with continuous publication online, to ensure timely, up-to-date research is available worldwide. The journal adheres to a rigorous and transparent peer review process, and all articles go through a statistical assessment to ensure robustness of the analyses. Open Heart is an official journal of the British Cardiovascular Society.