The impact of tRNA modifications on translation in cancer: identifying novel therapeutic avenues.

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

NAR cancer Pub Date : 2024-03-12 eCollection Date: 2024-03-01 DOI:10.1093/narcan/zcae012

Ana M Añazco-Guenkova, Borja Miguel-López, Óscar Monteagudo-García, Raquel García-Vílchez, Sandra Blanco

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引用次数: 0

Abstract

Recent advancements have illuminated the critical role of RNA modifications in post-transcriptional regulation, shaping the landscape of gene expression. This review explores how tRNA modifications emerge as critical players, fine-tuning functionalities that not only maintain the fidelity of protein synthesis but also dictate gene expression and translation profiles. Highlighting their dysregulation as a common denominator in various cancers, we systematically investigate the intersection of both cytosolic and mitochondrial tRNA modifications with cancer biology. These modifications impact key processes such as cell proliferation, tumorigenesis, migration, metastasis, bioenergetics and the modulation of the tumor immune microenvironment. The recurrence of altered tRNA modification patterns across different cancer types underscores their significance in cancer development, proposing them as potential biomarkers and as actionable targets to disrupt tumorigenic processes, offering new avenues for precision medicine in the battle against cancer.

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tRNA 修饰对癌症翻译的影响：确定新的治疗途径。

最近的研究进展揭示了 RNA 修饰在转录后调控中的关键作用，它们塑造了基因表达的全貌。这篇综述探讨了 tRNA 修饰是如何成为关键角色的，它们对功能进行微调，不仅维持了蛋白质合成的保真度，还决定了基因表达和翻译概况。我们系统地研究了细胞质和线粒体 tRNA 修饰与癌症生物学的交叉点，强调它们的失调是各种癌症的共同特征。这些修饰影响着细胞增殖、肿瘤发生、迁移、转移、生物能和肿瘤免疫微环境调控等关键过程。tRNA修饰模式的改变在不同癌症类型中反复出现，这凸显了它们在癌症发展中的重要意义，提出将它们作为潜在的生物标志物和可操作的靶点来破坏致瘤过程，为抗癌过程中的精准医疗提供了新的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NAR cancer

CiteScore

6.90

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍：