The missing hallmark of health: psychosocial adaptation.

IF 4.1 Q2 CELL BIOLOGY

Cell Stress Pub Date : 2024-03-12 eCollection Date: 2024-01-01 DOI:10.15698/cst2024.03.294

Carlos López-Otín, Guido Kroemer

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引用次数: 0

Abstract

The eight biological hallmarks of health that we initially postulated (Cell. 2021 Jan 7;184(1):33-63) include features of spatial compartmentalization (integrity of barriers, containment of local perturbations), maintenance of homeostasis over time (recycling & turnover, integration of circuitries, rhythmic oscillations) and an array of adequate responses to stress (homeostatic resilience, hormetic regulation, repair & regeneration). These hallmarks affect all eight somatic strata of the human body (molecules, organelles, cells, supracellular units, organs, organ systems, systemic circuitries and meta-organism). Here we postulate that mental and socioeconomic factors must be added to this 8×8 matrix as an additional hallmark of health ("psychosocial adaptation") and as an additional stratum ("psychosocial interactions"), hence building a 9×9 matrix. Potentially, perturbation of each of the somatic hallmarks and strata affects psychosocial factors and vice versa. Finally, we discuss the (patho)physiological bases of these interactions and their implications for mental health improvement.

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缺失的健康标志：社会心理适应。

我们最初提出的健康的八个生物学标志（《细胞》，2021 年 1 月 7 日；184(1):33-632021年1月7日；184(1):33-63），包括空间分隔（屏障的完整性、局部扰动的遏制）、长期保持稳态（循环与更替、电路整合、节律振荡）和一系列对压力的适当反应（稳态复原力、激素调节、修复与再生）。这些特征影响着人体的所有八个躯体层（分子、细胞器、细胞、超细胞单位、器官、器官系统、系统回路和元机体）。在此，我们推测，精神和社会经济因素必须作为健康的额外标志（"社会心理适应"）和额外层（"社会心理互动"）添加到这个 8×8 矩阵中，从而构建一个 9×9 矩阵。每个躯体特征和层的扰动都可能影响社会心理因素，反之亦然。最后，我们将讨论这些相互作用的（病理）生理基础及其对改善心理健康的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)

CiteScore

13.50

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.