Challenges and opportunities of medicines for treating tendon inflammation and fibrosis: A comprehensive and mechanistic review

IF 2.1 4区医学 Q3 PHARMACOLOGY & PHARMACY

Fundamental & Clinical Pharmacology Pub Date : 2024-03-11 DOI:10.1111/fcp.12999

Zohreh Najafi, Pouria Rahmanian-Devin PharmD, PhD, Vafa Baradaran Rahimi PharmD, PhD, Ali Nokhodchi PharmD, PhD, Vahid Reza Askari PharmD, PhD

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引用次数: 0

Abstract

Background

Tendinopathy refers to conditions characterized by collagen degeneration within tendon tissue, accompanied by the proliferation of capillaries and arteries, resulting in reduced mechanical function, pain, and swelling. While inflammation in tendinopathy can play a role in preventing infection, uncontrolled inflammation can hinder tissue regeneration and lead to fibrosis and impaired movement.

Objectives

The inability to regulate inflammation poses a significant limitation in tendinopathy treatment. Therefore, an ideal treatment strategy should involve modulation of the inflammatory process while promoting tissue regeneration.

Methods

The current review article was prepared by searching PubMed, Scopus, Web of Science, and Google Scholar databases. Several treatment approaches based on biomaterials have been developed.

Results

This review examines various treatment methods utilizing small molecules, biological compounds, herbal medicine-inspired approaches, immunotherapy, gene therapy, cell-based therapy, tissue engineering, nanotechnology, and phototherapy.

Conclusion

These treatments work through mechanisms of action involving signaling pathways such as transforming growth factor-beta (TGF-β), mitogen-activated protein kinases (MAPKs), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), all of which contribute to the repair of injured tendons.

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治疗肌腱炎症和纤维化药物的挑战与机遇：机理综述。

背景：肌腱病是指肌腱组织内胶原蛋白变性，同时伴有毛细血管和动脉增生，导致机械功能减退、疼痛和肿胀。虽然肌腱病中的炎症可以起到预防感染的作用，但不受控制的炎症会阻碍组织再生，导致纤维化和运动障碍：目标：无法控制炎症是治疗腱鞘炎的一大局限。因此，理想的治疗策略应包括调节炎症过程，同时促进组织再生：本综述文章是通过搜索 PubMed、Scopus、Web of Science 和 Google Scholar 数据库编写的。结果：这篇综述文章探讨了利用小分子材料进行治疗的各种方法：本综述探讨了利用小分子、生物化合物、草药启发疗法、免疫疗法、基因疗法、细胞疗法、组织工程、纳米技术和光疗法的各种治疗方法：这些疗法的作用机制涉及信号通路，如转化生长因子-β（TGF-β）、丝裂原活化蛋白激酶（MAPKs）和活化B细胞的核因子卡帕-轻链-增强因子（NF-κB），它们都有助于损伤肌腱的修复。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fundamental & Clinical Pharmacology 医学-药学

CiteScore

5.30

自引率

6.90%

发文量

111

审稿时长

6-12 weeks

期刊介绍： Fundamental & Clinical Pharmacology publishes reports describing important and novel developments in fundamental as well as clinical research relevant to drug therapy. Original articles, short communications and reviews are published on all aspects of experimental and clinical pharmacology including: Antimicrobial, Antiviral Agents Autonomic Pharmacology Cardiovascular Pharmacology Cellular Pharmacology Clinical Trials Endocrinopharmacology Gene Therapy Inflammation, Immunopharmacology Lipids, Atherosclerosis Liver and G-I Tract Pharmacology Metabolism, Pharmacokinetics Neuropharmacology Neuropsychopharmacology Oncopharmacology Pediatric Pharmacology Development Pharmacoeconomics Pharmacoepidemiology Pharmacogenetics, Pharmacogenomics Pharmacovigilance Pulmonary Pharmacology Receptors, Signal Transduction Renal Pharmacology Thrombosis and Hemostasis Toxicopharmacology Clinical research, including clinical studies and clinical trials, may cover disciplines such as pharmacokinetics, pharmacodynamics, pharmacovigilance, pharmacoepidemiology, pharmacogenomics and pharmacoeconomics. Basic research articles from fields such as physiology and molecular biology which contribute to an understanding of drug therapy are also welcomed.