Association Between Cancer and Cardiovascular Toxicity: A Nationwide Cross-Sectional Study on NHANES 1999–2018

IF 3.4 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Ruihuan Shen, Tong Zou
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Abstract

There is a dearth of evidence pertaining to the relationship of cardiovascular disease (CVD) and its subtype with adjudicated cancer, thereby limiting our understanding of the heightened risk of CVD resulting from long-term complications of cancer and its therapies. The aim of this study was to quantify the risks of CVD and its subtypes in adult cancer survivors compared with cancer-free controls in a nationwide cross-sectional study on Continuous National Health and Nutrition Examination Survey (NHANES). We included 44,442 participants ranging in age from 20 to 85 years. Cancer and CVD diagnoses were ascertained via the household questionnaires. The association of cancer status with the risk of CVD and CVD subtype was examined using weighted logistic regression. Stratification analyses were also performed by age, sex, race, marital status, income status, educational level, and hyperlipidemia. The Wald test was used to calculate P-value for interaction. A total of 4178 participants have cancer, while 4829 participants had CVD, respectively. In the multivariable-adjusted model, the cancer was consistently linked to an elevated risk of CVD. Stratification analyses showed that stronger association between cancer status and CVD risk was found in younger adults, non-white, and participants living without a spouse or partner, and without hyperlipidemia. Our study confirmed that cancer participants were strongly linked to living with CVD, independent of traditional cardiovascular risk factors, especially in younger adults, non-white, and participants living without a spouse or partner, and without hyperlipidemia. There exists a pressing requirement to establish effective strategies for the prevention of CVD within this population characterized by a heightened risk.

癌症与心血管毒性之间的关系:1999-2018 年 NHANES 全国横断面研究
有关心血管疾病(CVD)及其亚型与已判定癌症的关系的证据非常缺乏,因此限制了我们对癌症及其疗法的长期并发症导致心血管疾病风险增加的了解。本研究的目的是在连续性全国健康与营养调查(NHANES)的一项全国性横断面研究中,与无癌症对照组相比,量化成年癌症幸存者患心血管疾病及其亚型的风险。我们纳入了 44442 名参与者,他们的年龄从 20 岁到 85 岁不等。癌症和心血管疾病诊断是通过家庭问卷调查确定的。癌症状况与心血管疾病风险和心血管疾病亚型的关系采用加权逻辑回归法进行检验。此外,还按年龄、性别、种族、婚姻状况、收入状况、教育程度和高脂血症进行了分层分析。采用 Wald 检验计算交互作用的 P 值。共有 4178 人患有癌症,4829 人患有心血管疾病。在多变量调整模型中,癌症始终与心血管疾病风险升高相关。分层分析表明,癌症状况与心血管疾病风险之间的关联在年轻人、非白人、无配偶或伴侣、无高脂血症的参与者中更为明显。我们的研究证实,癌症患者与心血管疾病密切相关,不受传统心血管疾病风险因素的影响,尤其是在年轻人、非白人、无配偶或伴侣、无高脂血症的患者中。在这一具有高风险特征的人群中,迫切需要制定有效的心血管疾病预防策略。
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来源期刊
Cardiovascular Toxicology
Cardiovascular Toxicology 医学-毒理学
CiteScore
6.60
自引率
3.10%
发文量
61
审稿时长
>12 weeks
期刊介绍: Cardiovascular Toxicology is the only journal dedicated to publishing contemporary issues, timely reviews, and experimental and clinical data on toxicological aspects of cardiovascular disease. CT publishes papers that will elucidate the effects, molecular mechanisms, and signaling pathways of environmental toxicants on the cardiovascular system. Also covered are the detrimental effects of new cardiovascular drugs, and cardiovascular effects of non-cardiovascular drugs, anti-cancer chemotherapy, and gene therapy. In addition, Cardiovascular Toxicology reports safety and toxicological data on new cardiovascular and non-cardiovascular drugs.
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