The prevalence and disease course of autoimmune liver diseases in Greenland.

IF 1.3 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Rasmus Hvidbjerg Gantzel, Carina Nørskov Bagge, Gerda Elisabeth Villadsen, Karsten Fleischer Rex, Henning Grønbæk, Michael Lynge Pedersen
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引用次数: 0

Abstract

Autoimmune liver diseases are rare serious diseases causing chronic inflammation and fibrosis in the liver parenchyma and bile ducts. Yet, the prevalence and burden of autoimmune liver diseases are largely unexplored in Arctic native populations. We investigated the prevalence and management of autoimmune liver diseases in Greenland using nationwide cross-sectional register data and subsequent medical chart reviews validating diagnoses and extracting liver histology examinations and medical treatments. The overall prevalence of autoimmune liver diseases in Greenland was 24.6 per 100,000 (95% CI: 14.7-41.3). This was based on 7 patients with autoimmune hepatitis (AIH) (12.3 per 100,000), 3 patients with primary biliary cholangitis (PBC) (5.3 per 100,000), 4 patients with AIH/PBC overlap disease (7.0 per 100,000), and no patients with primary sclerosing cholangitis. All diagnoses were confirmed by liver histology examinations. Medical treatments adhered to internal recommendations and induced complete remission in most patients with AIH, and complete or partial remission in 1 patient with PBC and 3 patients with AIH/PBC overlap disease. One patient had established cirrhosis at the time of diagnosis, while 2 patients progressed to cirrhosis. In conclusion, the prevalence of autoimmune liver diseases was lower in Greenland than in Scandinavia and among Alaska Inuit.

格陵兰岛自身免疫性肝病的发病率和病程。
自身免疫性肝病是一种罕见的严重疾病,会引起肝实质和胆管的慢性炎症和纤维化。然而,自身免疫性肝病在北极地区原住民中的发病率和负担在很大程度上尚未得到研究。我们利用全国范围内的横断面登记数据和随后的病历审查验证了诊断结果,并提取了肝脏组织学检查和治疗方法,调查了格陵兰岛自身免疫性肝病的患病率和管理情况。格陵兰岛自身免疫性肝病的总发病率为每10万人中有24.6人(95% CI:14.7-41.3)。其中包括7名自身免疫性肝炎(AIH)患者(每10万人中有12.3人)、3名原发性胆汁性胆管炎(PBC)患者(每10万人中有5.3人)、4名AIH/PBC重叠症患者(每10万人中有7.0人),以及没有原发性硬化性胆管炎患者。所有诊断均经肝脏组织学检查确诊。医学治疗符合内部建议,大多数 AIH 患者的病情完全缓解,1 名 PBC 患者和 3 名 AIH/PBC 重症患者的病情完全缓解或部分缓解。1 名患者在确诊时已发展为肝硬化,2 名患者发展为肝硬化。总之,格陵兰岛自身免疫性肝病的发病率低于斯堪的纳维亚半岛和阿拉斯加因纽特人。
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来源期刊
International Journal of Circumpolar Health
International Journal of Circumpolar Health 医学-公共卫生、环境卫生与职业卫生
CiteScore
2.10
自引率
15.40%
发文量
51
审稿时长
6-12 weeks
期刊介绍: The International Journal of Circumpolar Health is published by Taylor & Francis on behalf of the Circumpolar Health Research Network [CircHNet]. The journal follows the tradition initiated by its predecessor, Arctic Medical Research. The journal specializes in circumpolar health. It provides a forum for many disciplines, including the biomedical sciences, social sciences, and humanities as they relate to human health in high latitude environments. The journal has a particular interest in the health of indigenous peoples. It is a vehicle for dissemination and exchange of knowledge among researchers, policy makers, practitioners, and those they serve. International Journal of Circumpolar Health welcomes Original Research Articles, Review Articles, Short Communications, Book Reviews, Dissertation Summaries, History and Biography, Clinical Case Reports, Public Health Practice, Conference and Workshop Reports, and Letters to the Editor.
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